PHOSPHORAMIDITE BUILDING BLOCKS FOR SUGAR-CONJUGATED OLIGONUCLEOTIDES
Novel nucleoside phosphoramidite building blocks for preparation of synthetic oligonucleotides containing at least one phosphotriester linkage conjugated to a monosaccharide and synthetic processes for making the same are disclosed. Furthermore, oligomeri
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Paragraph 0173
(2016/04/19)
(2-Acetoxyphenoxy)ethyl (APOe) as a phosphate protecting group in solid-phase synthesis of oligonucleotides via the phosphoramidite approach
The (2-Acetoxyphenoxy)ethyl (APOe) group could be an alternative to the conventional 2-cyanoethyl group for phosphate protection in solid-phase oligonucleotide synthesis to circumvent DNA alkylation by acrylonitrile generated under basic condition. This g
Cheruvallath, Zacharia S.,Eleuteri, Alessandra,Turney, Brett,Ravikumar, Vasulinga T.
p. 251 - 256
(2012/12/22)
Method of preparing phosphoramidites
Improved methods for preparation of phosphoramidite compounds are disclosed. The phosphoramidites are useful, for example, for the preparation of oligonucleotides by solid state oligonucleotide synthetic regimes.
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Example 9
(2008/06/13)
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