Squaric acid derivatives prevent the removal of N-Cbz and N-Fmoc groups under catalytic hydrogenation reaction
Under the catalytic hydrogenation conditions (H2/Pd-C), squaric acid derivatives 4 and 7 were found to be effective additives for chemoselective reduction of olefins and an alkyne having an N-Cbz or N-Fmoc group where the amino group remained to be protected. Benzyl esters having an N-Cbz or N-Fmoc group we re also selectively removed to give the corresponding N-protected carboxylic acids.
Shinada,Hayashi,Yoshida,Ohfune
p. 1506 - 1508
(2007/10/03)
LES ORGANOCUPRATES DANS UNE NOUVELLE SYNTHESE D'AMINOACIDES ENANTIOMERIQUEMENT PURS
A new general method of synthesis of optically pure α- amino esters was elaborated during studies on the reaction of organocuprates with tosyl and halogeno derivatives of L-serine and L-homoserine.
Bajgrowicz, J. A.,Hallaoui, A. El,Jacquier, R.,Pigiere, Ch.,Viallefont, Ph.
p. 1833 - 1845
(2007/10/02)
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