- Synthesis of Enantiopure C3-Symmetric Triangular Molecules
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An asymmetric synthesis of C3-symmetric triangular macrocycles is reported. 1-Methylsulfonyl-4-(4-vinylphenyl)-1,2,3-triazole undergoes a rhodium(II)-catalyzed cyclotrimerization to establish an enantiopure C3-symmetric triangular ma
- Miura, Tomoya,Nakamuro, Takayuki,Stewart, Scott G.,Nagata, Yuuya,Murakami, Masahiro
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- Site-Selective Csp3-Csp/Csp3-Csp2Cross-Coupling Reactions Using Frustrated Lewis Pairs
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The donor-acceptor ability of frustrated Lewis pairs (FLPs) has led to widespread applications in organic synthesis. Single electron transfer from a donor Lewis base to an acceptor Lewis acid can generate a frustrated radical pair (FRP) depending on the s
- Dasgupta, Ayan,Stefkova, Katarina,Babaahmadi, Rasool,Yates, Brian F.,Buurma, Niklaas J.,Ariafard, Alireza,Richards, Emma,Melen, Rebecca L.
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supporting information
p. 4451 - 4464
(2021/04/07)
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- Zinc-Catalysed Hydroboration of Terminal and Internal Alkynes
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A regioselective hydroboration of alkynes has been developed by using commercially available zinc triflate as a catalyst, in the presence of catalytic amount of NaBHEt3. The reaction tolerates a wide range of terminal alkynes having several synthetically useful functional groups and proceeds regioselectively to furnish hydroborated products in moderate to excellent yields. This system shows moderate chemoselectivity towards terminal C≡C bond over terminal and internal C=C bond and internal C≡C bond.
- Mandal, Souvik,Mandal, Sayantan,Geetharani
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p. 4553 - 4556
(2019/08/20)
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- Method for synthesizing alkyne through catalytic asymmetric cross coupling (by machine translation)
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The invention belongs to the field of, asymmetric synthesis, and discloses a method for catalyzing asymmetric cross- coupling to synthesize: an alkyne, and the L method comprises, the following steps, of A: preparing B a cuprous, salt and C a: ligand; preparing a catalyst; adding a base; reacting the compound with the compound with the compound; and reacting the compound with the compound. Of these, one of them, X is selected from the group consisting of, R halogens. 1 Optionally substituted heteroarylsulfonylcyanamide groups selected from the, group consisting, of optionally substituted, phenyl groups In-flight vehicle, R6 Trialkyl silyl groups or alkyl radicals, R2 Cycloalkyl radicals optionally substituted with an, optionally substituted alkyl, (CH radical2 )n R4 Multi,layer chain, n=0-10,R saw blade4 A group selected, from, the group consisting of phenyl, alkenyl, aralkynyls, noonyloxy,and, noonylsulfonylsulfonylsulfonylsulfonylsulfonylsulfonylsulfonylsulfonylsulfonylsulphonylsulphonylsulphonylsulphonylsulphonylsulphonylsulphonylsulphonylsulphonylsulphonylphenyl disiloxy-radicals. R3 A ligand, selected from hydrogen or any of the functional groups, is selected from the group consisting of, hydrogen and any L other functional group. The method, R disclosed by the, A invention has the, advantages of good catalytic, R ’ effect, wide application range. and high catalytic efficiency, and the, method disclosed by the, invention has the. advantages of good catalytic effect, wide application range and high catalytic efficiency. (by machine translation)
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Paragraph 0171-0173; 0175-0177
(2020/01/12)
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- Nickel-Catalyzed Highly Regioselective Hydrocyanation of Terminal Alkynes with Zn(CN)2 Using Water as the Hydrogen Source
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The first efficient and general nickel-catalyzed hydrocyanation of terminal alkynes with Zn(CN)2 in the presence of water has been developed. The reaction provides a regioselective protocol for the synthesis of functionalized vinyl nitriles with a range of structural diversity under mild reaction conditions while obviating use of the volatile and hazardous reagent of HCN. Deuterium-labeling experiments confirmed the role of water as the hydrogen source in this hydrocyanation reaction.
- Zhang, Xingjie,Xie, Xin,Liu, Yuanhong
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supporting information
p. 7385 - 7389
(2018/06/11)
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- Palladium catalysed regio- and stereoselective synthesis of (E)-4-aryl-1,3-bis(trimethylsilyl)but-3-en-1-ynes
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A practical and general synthetic approach to a series of 4-aryl-but-3-en-1-ynes is described. In the presence of palladium complexes a variety of aryl bromides (or iodides) undergo coupling with two equivalents of trimethylsilylacetylene with the formati
- Rogalski, Szymon,Kubicki, Maciej,Pietraszuk, Cezary
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p. 6192 - 6198
(2018/09/17)
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- MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS
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Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
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Paragraph 00621; 00791
(2018/09/12)
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- Solution processable polyamines via click chemistry for water purification
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Amine functionalised polymers are not widely used in applications owing to increased reactivity, sensitivity to air and moisture, low stability and processing difficulties. Here, we report a convergent strategy for the synthesis of four stable and process
- Goud, Vanga Devendar,Dsouza, Roshan,Valiyaveettil, Suresh
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p. 47647 - 47658
(2015/06/16)
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- A qualitative examination of the effects of silicon substituents on the efficiency of cross-coupling reactions
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A qualitative study of the effects of various substituents on the silicon atom in cross-coupling reactions of alkenylsilanes has been carried out. In intermolecular competition experiments, the influence of carbon-based groups (methyl, ethyl, isopropyl, tert-butyl, phenyl, and 3,3,3-trifluoropropyl) and alkoxy groups (monoethoxydimethyl-, diethoxymethyl-, and triethoxy) on the silicon have been evaluated under activation by two different methods, fluoride (TBAF) and silanolate (TMSOK). The influence of the substituents was highly dependent on the method of activation. In the presence of TBAF, there was only a modest steric effect (except for tert-butyl substituents), and the efficiency decreased slightly with increasing numbers of alkoxy groups. In the presence of TMSOK, a significant steric effect was noted, but the number of alkoxy groups had almost no influence. These trends were interpreted in terms of the divergent mechanisms for the cross-coupling process.
- Denmark, Scott E.,Neuville, Luc,Christy, Matthew E. L.,Tymonko, Steven A.
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p. 8500 - 8509
(2007/10/03)
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- Orthogonal approaches to the simultaneous and cascade functionalization of macromolecules using click chemistry
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The development of selective chemistries that are orthogonal to the diverse array of functional groups present in many polymeric systems is becoming an important tool for the synthesis and use of macromolecules in fields ranging from biomedical devices to
- Malkoch, Michael,Thibault, Raymond J.,Drockenmuller, Eric,Messerschmidt, Martin,Voit, Brigitte,Russell, Thomas P.,Hawker, Craig J.
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p. 14942 - 14949
(2007/10/03)
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