Cytotoxicity of semisynthetic acetal triterpenes from one-pot vicinal diol cleavage following by lactolization: Reaction promoted by NaIO 4/SiO2 gel in THF
In situ C-C bond cleavage of vicinal diol following by the lactolisation resulted from separated treatment of Arjunolic acid (1), 24-hydroxytormentic acid (2) and 3-O-β-D-glucopyranosylsitosterol (3) with sodium periodate and silica gel in dried THF according to the strategic position of hydroxyl functions in the molecule. The reaction led to a lactol pentacyclic triterpenes 1A, 2A and a bicyclotriacetal of β-sitosterol 3A. These products were further acetylated and the cytotoxicity of all molecules was evaluated against human fibrosarcoma HT1080 cancer cells lines.
Sandjo, Louis Pergaud,Djoumessi, Aurelie Vigee Barry Songfack,Rincheval, Vincent,Poumale, Herve Martial Poumale,Abegaz, Berhanu M.,Ngadjui, Bonaventure T.
p. 711 - 718
(2013/06/05)
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