- New triterpenoid saponin glycosides from the fruit fibers of: Trichosanthes cucumerina L.
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Five new triterpenoid saponin glycosides, trichocucumerisides A-E (1-5), together with eleven known compounds (6-16) were isolated from Trichosanthes cucumerina fruit fibers. The structures of the new compounds were elucidated by detailed analysis of NMR and mass spectroscopic data as well as chemical reactions. The anti-inflammatory study against nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 cells shows that compounds 7 and 9 exhibited stronger NO inhibitory activity, with IC50 values of 3.0 and 2.7 μM, respectively, with comparison to positive references Celecoxib and aminoguanidine (IC50 values 75.7 and 75.0 μM, respectively). Compounds 7 and 9 also possessed a greater selectivity index (SI) of approximately 3-4-fold activity than that of the positive references.
- Chulrik, Wanatsanan,Chunglok, Warangkana,Li, Jian-Xin,Suebsakwong, Parichat,Suksamrarn, Apichart,Yao, Zhu-Jun
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p. 10461 - 10470
(2020/03/27)
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- Artefact formation during acid hydrolysis of saponins from Medicago spp.
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Artefact compounds obtained during acid hydrolysis of saponins from Medicago spp. (Fabaceae), have been monitored and evaluated by GC-FID. Their identification has been performed by GC-MS and 1H and 13C NMR. Saponins with different substituents on the triterpenic pentacyclic aglycones were considered, and their hydrolysis products were detected and quantified during 10?h of time course reaction. From soyasapogenol B glycoside the well known soyasapogenols B, C, D and F were obtained together with a previously undescribed sapogenol artefact identified as 3β,22β,24-trihydroxyolean-18(19)-en and named soyasapogenol H. From a zanhic acid saponin two major artefact compounds identified as 2β,3β,16α-trihydroxyolean-13(18)-en-23,28-dioic acid and 2β,3β,16α-trihydroxyolean-28,13β-olide-23-oic acid were obtained, together with some zanhic acid. Other compounds, detected in very small amount in the reaction mixture, were also tentatively identified based on their GC-MS and UV spectra. The other most characteristic saponins in Medicago spp., hederagenin, bayogenin and medicagenic acid glycosides, under acidic condition of hydrolysis, released instead the correspondent aglycones and generated a negligible amount of artefacts. Nature of artefacts and mechanism of their formation, involving a stable tertiary carbocation, is here proposed and discussed for the first time.
- Tava, Aldo,Biazzi, Elisa,Mella, Mariella,Quadrelli, Paolo,Avato, Pinarosa
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p. 116 - 127
(2017/04/13)
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- A new biologically active triterpenoid saponin from the aerial parts of Neanotis wightiana
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Phytochemical investigation of the aerial parts of Neanotis wightiana for the first time has led to the isolation of one new triterpenoid saponin, neanoside A (1), along with seven known compounds, oleanolic acid (2), ursolic acid (3), β-sitosterol (4) and its glucoside (5), stigmasterol (6) and its glucoside (7) and hexacosanoic acid (8). The structures of these compounds were elucidated by means of spectroscopic (NMR, MS and other) and chemical techniques as well as comparison with literature data. The structure of 1 was elucidated as 3-O-α-l-rhamnopyranosyl-(1 → 2)-β-d-xylopyranosyl (1 → 3)-β-d-glucopyranosyl bayogenin. The in vitro biochemical analysis of compound 1 against the activity of human serum liposomal enzymes, SGOT (serum glutamate oxaloacetate transaminase), SGPT (serum glutamate pyruvate transaminase) and ALP (alkaline phosphatase) and glycerol kinase showed significant reduction of their activity.
- Das, Niranjan,Ghosh, Partha Sarathi,Das, Manash Chandra,Dinda, Biswanath
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p. 270 - 273
(2013/08/25)
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- Oleanane saponins from Bellis sylvestris Cyr. and evaluation of their phytotoxicity on Aegilops geniculata Roth
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Six oleanane saponins were isolated for the first time from leaves of Bellis sylvestris Cyr., the southern daisy. Their structures were established by the extensive use of 2D-NMR experiments, including COSY, TOCSY, NOESY, HSQC, HMBC, CIGAR, H2BC, and HSQC-TOCSY, along with Q-TOF HRMS2 analysis. All of the compounds are constituted by bayogenin as aglycone, and characterized by the presence of an oligosaccharide moiety, consisting of two to four sugar unities esterified at the C-28 carboxyl carbon. One of the isolated compounds is a bisdesmoside containing an additional sugar moiety at the C-3 carbon. The phytotoxic activity assayed against Aegilops geniculata Roth., a coexisting test species, has been evaluated revealing that all the compounds, at the highest concentrations, showed strong phytotoxicity against the leaf development.
- Scognamiglio, Monica,D'Abrosca, Brigida,Fiumano, Vittorio,Chambery, Angela,Severino, Valeria,Tsafantakis, Nikolaos,Pacifico, Severina,Esposito, Assunta,Fiorentino, Antonio
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p. 125 - 134,10
(2012/12/12)
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- A new complex triterpenoid saponin from Samanea saman with haemolytic activity and adjuvant effect
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A new complex triterpenoid saponin was isolated from the stem bark of Samanea saman by using chromatographic methods. Its structure was established as 3-[(2-O-β-d-glucopyranosyl-β-d-glucopyranosyl)oxy]-2,23-dihydroxy- (2β,3β,4α)-olean-12-en-28-oic acid O-β-d-glucopyranosyl-(1 → 3)-O-[O-β-d-glucopyranosyl-(1 → 4)]-O-6-deoxy-α-l- mannopyranosyl-(1 → 2)-6-O-[4-O-[(2E,6S)-2,6-dimethyl-1-oxo-2,7-octadienyl] -6-deoxy-α-l-mannopyranosyl)oxy]-β-d-glucopyranosyl ester (1). Structural elucidation was performed using detailed analyses of 1H and 13C NMR spectra including 2D NMR spectroscopic techniques and chemical conversions. The haemolytic activity of the saponin was evaluated using in vitro assays, and its adjuvant potential on the cellular immune response against ovalbumin antigen was investigated using in vivo models.
- Barbosa, Antony De Paula,Da Silva, Bernadete Pereira,Parente, José Paz
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experimental part
p. 626 - 631
(2012/10/07)
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- Medicinal flowers. XXXII.1) Structures of oleanane-type triterpene saponins, perennisosides VIII, IX, X, XI, and XII, from the flowers of Bellis perennis
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Five new triterpene saponins perennisosides VIII (1), IX (2), X (3), XI (4), and XII (5) were isolated from the MeOH-eluated fraction of the methanolic extract from the flowers of Bellis perennis. The MeOH-eluted fraction of the methanolic extract from the flowers of B. perennis was found to inhibit gastric emptying in olive oil-loaded mice at a dose of 200 mg/kg, per os (p.o.). The stereostructures of 1-5 were elucidated on the basis of chemical and spectroscopic evidence.
- Morikawa, Toshio,Li, Xuezheng,Nishida, Eriko,Nakamura, Seikou,Ninomiya, Kiyofumi,Matsuda, Hisashi,Hamao, Makoto,Muraoka, Osamu,Hayakawa, Takao,Yoshikawa, Masayuki
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experimental part
p. 889 - 895
(2011/08/21)
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- New saponins from Sechium mexicanum
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The chemical study of Sechium mexicanum roots led to the isolation of the two new saponins {3-0-β-d-glucopyranosyl (1→3)-β-d- glucopyranosyl-2β,3β,16α,23-tetrahydroxyolean-12-en-28-oic acid 28-0-α-l-rhamnopyranosyl-(1→3)-β-d- xylopyranosyl-(1→4)- α-l-rham
- Hernandez-Carlos, Beatriz,Carmona-Pineda, Miriam,Villanueva-Canongo, Claudia,Lopez-Olguin, Jesus F.,Aragon-Garcia, Agustin,Joseph-Nathan, Pedro
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experimental part
p. 994 - 1003
(2010/06/15)
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- Cytotoxic 16-β-[(d-xylopyranosyl)oxy]oxohexadecanyl triterpene glycosides from a Malagasy plant, Physena sessiliflora
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Brine shrimp lethality assay-guided separation of the MeOH extract of leaves of Physena sessiliflora, which is endemic to Madagascar, afforded eight triterpene glycosides, Physenoside S1-4 and 16-β-[(d-xylopyranosyl)oxy]oxohexadecanyl homologues, Physenos
- Inoue, Masaki,Ohtani, Kazuhiro,Kasai, Ryoji,Okukubo, Mayu,Andriantsiferana, Marta,Yamasaki, Kazuo,Koike, Tohru
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experimental part
p. 1195 - 1202
(2010/06/21)
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- New triterpenic saponins from the aerial parts of Medicago arabica (L.) Huds
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The reinvestigation of saponin composition from Medicago arabica from Italy allowed the detection of nineteen (1-19) saponins. All of them were purified by reverse-phase chromatography and their structures elucidated by spectroscopic and spectrometric (1D and 2D NMR; ESI-MS/MS) and chemical methods. Fourteen were known saponins, previously found in other plants including other Medicago species. They have been identified as glycosides of oleanolic acid, 2β,3β-dihydroxyolean-12-en-28-oic acid, hederagenin, bayogenin and soyasapogenol B. Five saponins, identified as 3-O-[-α-L- arabinopyranosyl(1→2)-β-D-glucuronopyranosyl]-30-O-β-D- glucopyranosyl 2β,3β,30-trihydroxyolean-12-en-28-oic acid (1), 3-O-[α-L-arabinopyranosyl(1→2)-β-D-glucuronopyranosyl] -30-O-[β-D-glucopyranosyl]3β,30-dihydroxyolean-12-en-28-oic acid (2), 3-O-|β-D-glucuronopyranosyl]-30-O-[α-L-arabinopyranosyl(1→2) -β-D-glucopyranosyl] 2β,3β,30-trihydroxyolean-12-en-28-oic acid (3), 3-O-[β-D-glucuronopyranosyl]-30-O-[α-L- arabinopyranosyl(1→2)-β-D-glucopyranosyl] 3β,30-dihydroxyolean- 12-en-28-oic acid (4) and 3-O-[β-D-glucuronopyranosyl]-30-O-[β-D- glucopyranosyl] 2β,3β,30-trihydroxyolean-12-en-28-oic acid (5), are reported here as new natural compounds. These new saponins, possessing a hydroxy group at the 30-methyl position of the triterpenic skeleton, have never been previously found in the genus Medicago.
- Tava, Aldo,Mella, Mariella,Avato, Pinarosa,Biazzi, Elisa,Pecetti, Luciano,Bialy, Zbigniew,Jurzysta, Marian
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experimental part
p. 2826 - 2835
(2010/06/11)
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- Triterpene glycosides from the tubers of Anemone coronaria
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Six new triterpene glycosides (1-6), together with 11 known ones (7-17), have been isolated from a glycoside-enriched fraction prepared from the tubers of Anemone coronaria L. (Ranunculaceae). On the basis of extensive spectroscopic analysis, including 2D
- Mimaki, Yoshihiro,Watanabe, Kazuki,Matsuo, Yukiko,Sakagami, Hiroshi
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experimental part
p. 724 - 729
(2010/02/28)
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- Four new triterpenoid saponins from Conyza blinii
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Three new bisdesmosidic saponins named conyzasaponins A, B, and C (1-3) and one new monodesmosidic saponin, conyzasaponin G (4), were isolated from the aerial parts of Conyza blinii. Their structures were elucidated on the basis of extensive NMR (DEPT, DQF-COSY, HOHAHA, HMQC, HMBC, and NOESY) and MS studies. Compounds 1-3 share a common prosapogenin, bayogenin 3-?-β-D-xylopyranosyl-(1→3)-β-D-glucopyran oside, which is identical with conyzasaponin G (4), and differ in the structures of the esterlinked sugar moieties at C-28. Conyzasaponin A (1) is the 28-?-β-D-apiofuranosyl-(1→3)-β-D-xylopyran osyl-(1→4)-α-L-rhamnopyranosyl-(1→2)-α-L-ar abinopyranosyl ester, conyzasaponin B (2), the 28-?-β-D-apiofurano-syl-(1→3)-β-D-xylopyra nosyl-(1→4)-[α-L-arabinopyranosyl-(1→3)]-α- L-rhamnopyranosyl-(1→2)-α-L-arabinopyranosyl ester, and conyzasaponin C (3), the 28-?-α-L-rhamnopyranosyl-(1→3)-β-D-xylopy ranosyl-(1→4)-[β-D-apiofuranosyl-(1→3)]-α-L- rhamnopyranosyl-(1→2)-α-L-arabinopyranosyl ester of the prosapogenin, respectively.
- Su, Yanfang,Guo, Dean,Guo, Hongzhu,Liu, Jiansheng,Zheng, Junhua,Koike, Kazuo,Nikaido, Tamotsu
-
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- Phenolic and triterpenoid glycosides from Aster batangensis
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A new phenolic glycoside, asterbatanoside A [p-hydroxyacetophenone-4-O-β-D-xylopyranosyl-(1 → 6)-β-D-glucopyranoside], and two new triterpenoid saponins, asterbatanoside B [2α,3β,23-trihydroxyolean-12-en-28-oic acid-28-O-β-D-glucopyranosyl-(1 → 6)-β-D-glucopyranoside] and asterbatanoside C [3-O-β-D-glucopyranosyl-2β,3β,23-trihydroxyolean-12-en-28- oicacid-28-O-β-D-glucopyranoside] were isolated from the roots of Aster batangensis. Their structures were determined by spectroscopic methods and chemical evidence. The total synthesis of asterbatanoside A is also reported. Copyright
- Shao, Yu,Li, Yun Long,Zhou, Bing Nan
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p. 1593 - 1598
(2007/10/03)
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- TRITERPENE SAPONOINS FROM ASTER YUNNANENSIS
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Four new triterpene saponins, asteryunnanosides A, B, C and D, have been isolated from Aster yunnanensis and their structures deduced as 2α,3β,23-trihydroxyolean-12-en-28-oic acid-28-O-α-L-rhamnopyranosyl-(1->2)-β-D-glucopyranoside, 2α,3β,23-trihydroxyolean-12-en-28-oic acid-28-O-β-D-glucopyranosyl-(1->2)-β-D-glucopyranoside, 2α,3β-dihydroxyolean-12-en-28-oic acid-28-O-α-L-rhamnopyranoside-(1->2)-β-D-glucopyranoside and 2α,3β-dihydroxyolean-12-en-28-oic acid-28-O-β-D-glucopyranosyl-(1->2)-β-D-glucopyranoside, respectively, by means of spectral and chemical data. - Key words: Aster yunnanesis; Compositae; triterpene saponins; asteryunnanosides A, B, C, D; arjunolic acid; maslinic acid.
- Shao, Yu,Zhou, Bing-Nan,Lin, Long-Ze,Cordell, Geoffrey A.
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p. 1487 - 1492
(2007/10/02)
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- New triterpenoid saponins, asterbatanoside D and E, from Aster batangensis
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Two new triterpenoid saponins named asterbatanoside D and E have been isolated from Aster batangensis and their structures elucidated as 3-O-β-D-glucopyranosyl-bayogenin-28-O-β-D-glucopyranosyl (1→6)-β-D-glucopyranoside and 3-O-6'-acetyl-β-D-glucopyranosyl-bayogenin-28-O-β-D-glucopyranosyl-( 1→6)-β-D-glucopyranoside by means of MS, 1D and 2D NMR techniques (COSY, TOCSY, ROESY, HMQC, and HMBC), and chemical reactions.
- Shao,Zhou,Ma,Wu
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p. 246 - 249
(2007/10/02)
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- Studies on the constituents of Polygala japonica HOUTT. I. Structures of polygalasaponins I-X
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Ten new oleanane-type saponins, polygalasaponins I-X, along with two known saponins, bayogenin-3-O-β-D-glucopyranoside and lobatoside B were isolated from the aerial part of Polygala japonica HOUTT. The structures of these compounds were established on the basis of spectroscopic and chemical evidence.
- Zhang,Miyase,Kuroyanagi,Umehara,Ueno
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p. 115 - 120
(2007/10/02)
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- Studies on the constituents of Polygala japonica HOUTT. II. Structures of polygalasaponins XI-XIX
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Nine new oleanane-type saponins polygalasaponins XI-XIX were isolated from the aerial part of Polygala japonica. The structures of these compounds were established on basis of spectroscopic and chemical evidence.
- Zhang,Miyase,Kuroyanagi,Umehara,Ueno
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p. 966 - 970
(2007/10/03)
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- TRITERPENOIDS AND THEIR GLYCOSIDES FROM TERMINALIA CHEBULA
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Two new triterpenoid glycosides, chebuloside I and II were isolated from the stem bark of Terminalia chebula and shown to be β-D-galactopyranosyl 2α,3β,23-trihydroxyolean-12-en-28-oate and β-D-glucopyranosyl 2α,3β,6β,23-tetrahydroxyolean-12-en-28-oate, respectively, based on their spectral data and some chemical transformations. Key Word Index - Terminalia chebula; Combretaceae; stem bark; arjunolic acid; terminolic acid; chebuloside I, II; triterpenoids; triterpenoid glycosides.
- Kundu, Asish,Mahato, Shashi B.
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p. 999 - 1002
(2007/10/02)
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- TRITERPENOIDS FROM ANAMIRTA COCCULUS
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One new triterpenoid, 2α,3β,23-trihydroxy-11α,12α-epoxyolean-28,13β-olide and two new triterpenoid glycosides, β-D-glucopyranosyl-2β,3β,23-trihydroxyolean-12-en-28-oate and 2α,3β-dihydroxy-23-β-D-glucopyranosyloxyolean-12-en-28-oic acid, are reported from the stem of Anamirta cocculus.The major compounds isolated are the already known 2α,3β,23-trihydroxyolean-12-en-28-oic acid (arjunolic acid) and its 28-O-β-D-glucopyranoside.None of the isolated compounds showed any molluscicidal or antifungal activity.
- Jayasinghe, Lalith,Wannigama, G. Percy,Macleod, John K.
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p. 1111 - 1116
(2007/10/02)
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- Studies on the constituents of Actinostemma lobatum MAXIM. IV. Structures of Lobatosides C, D and H, the dicrotalic acid esters of bayogenin bisdesmosides isolated from the herb.
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Eight bayogenin glycosides, lobatosides A-H, were isolated from the herb of Actinostemma lobatum MAXIM.(Curcurbitaceae).The isolation of lobatosides A-H and the structures of lobatosides A, C, D and H are described.Lobatoside A is 3-O-2)-β-D-glucopyranosyl>bayogenin (2β,3β,23-trihydroxyolean-12-en-28-oic acid).Lobatosides C, D and H are dicrotalic acid (3-hydroxy-3-methylglutaric acid) esters of the 28-2)-α-L-arabinopyranosyl>ester, 28-3)-αL-rhamnopyranosyl-(1->2)-α-L-arabinopyranosyl>ester and 28-3)-α-L-rhamnopyranosyl-(1->2)-α-L-arabinopyranosyl>ester of lobatoside A, respectively.Dicrotalic acid is linked at one end to the C4hydroxyl group of the α-L-arabinopyranosyl group in the C3-linked sugar moiety, and at the order end to the C4-hydroxyl group of the α-L-rhamnopyranosyl group in the ester-linked sugar moiety to form a macrocyclic structure ("cyclic bisdesmoside").Lobatoside H was proved to be identical with tubeimoside I isolated from the tuber of Bolbostemma paniculatum (MAXIM).FRANQUET(Cucurbitaceae).Keywords - Actinostemma lobatum; Cucurbitaceae; oleanane-type triterpene glycoside; bayogenin; 2β,3β,23-trihydroxyolean-12-en-28-oic acid; lobatoside;,tubeimoside I; cyclic bisdesmoside; dicrotalic acid; 3-hydroxy-3-methylglutaric acid.
- Fujioka, Toshihiro,Masayo, Iwamoto,Iwase, Yukiko,Hachiyama, Shizuko,Okabe, Hikaru,et. al
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p. 1770 - 1775
(2007/10/02)
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- Studies on the constituents of Actinostemma lobatum MAXIM. V. Structures of Lobatosides B,E,F and G, the dicrotalic acid esters of bayogenin bisdesmosides isolated from the herb
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The structures of lobatosides B, E, F and G, the dicrotalic acid esters of bayogenin bisdesmosides isolated from the herb of Actinostemma lobatum MAXIM. (Cucurbitaceae), were determined on the basis of chemical and spectral evidence.Lobatoside B is the dicrotalic acid (3-hydroxy-3-methylglutaric acid ) ester of 3-O-2)-β-D-glucopyranosyl>bayogenin 28-2)-α-L-arabinopyranosyl> ester.Dicrotalic acid is linked at one end to the C6-hydroxyl group of the terminal β-D-glucopyranosyl group in the C3-linked sugar moiety, and at the other end to the C4-hydroxyl group of the α-L-rhamnopyranosyl group in the ester-linked sugar moiety to form a macrocyclic structure (cyclic bisdesmoside).Lobatosides E, F and G are cyclic bisdesmosides of bayogenin similar to lobatoside B, but different in the numbers and species of the component sugars and positions of the ester linkages of the dicrotalic acid.Keywords - Actinostemma lobatum; Cucurbitaceae; lobatoside; bayogenin glycoside; cyclic bisdesmoside; dicrotalic acid; NOE difference spectrum; decoupling difference spectrum.
- Fujioka, Toshihiro,Iwamoto, Masayo,Iwase, Yukiko,Hachiyama, Shizuko,Okabe, Hikaru,et al.
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p. 2355 - 2360
(2007/10/02)
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- Saponins from Bolbostemma paniculatum: Cyclic bisdesmosides, tubeimosides II and III
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The isolation and structural determination of tubeimosides II and III, new cyclic bisdesmosides from tubers of Bolbostemma paniculatum are reported.
- Kasai, Ryoji,Miyakoshi, Masazumi,Nie, Rui-Lin,Zhou, Jun,Matsumoto, Kazuhiro,Morita, Toshinobu,Nishi, Masatoshi,Miyahara, Kazumoto,Tanaka, Osamu
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p. 1439 - 1446
(2007/10/02)
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- STRUCTURAL ELUCIDATION OF ALFALFA ROOT SAPONINS BY MASS SPECTROMETRY AND NUCLEAR MAGNETIC RESONANCE ANALYSIS
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Structures of saponins may be fully elucidated using a combination of n.m.r. and m.s. instead of the usual degradation techniques.Well resolved proton n.m.r. spectra and chromatographic separation can be obtained from peracetylated mixtures of saponins.Under these conditions, genins are identified mainly by (13)C n.m.r. spectroscopy; sugars and their points of attachment are determined by examining (1)H chemical shifts and coupling constants following assignments made by 2D COSY and relayed COSY experiments.Sugar chains are sequenced by observing intersugar connectivities through long-range couplings (delayed COSY) or n.O.e.Alternatively, the use of Californium plasma desorption m.s. provides quasimolecular ions and fragments corresponding to the sequential rupture of the chain of sugars.Free carboxylic acids are located on an acetylated saponin by looking at the disappearance, in the presence of Eu complexes, of the carbon situated α to the carbonyl in the (13)C n.m.r. spectrum.The above methods have been employed to determine the structures of the seven major saponins of alfalfa root, which are allegedly responsible for the antifeedant properties of the vegetable.
- Massiot, Georges,Lavaud, Catherine,Men-Olivier, Louisette Le,Binst, Georges Van,Miller, Stephen P. F.,Fales, Henry M.
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p. 3071 - 3080
(2007/10/02)
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- Further SAponins from Phytolacca dodecandra L'HERIT
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Three new bidesmosidic saponins 1-3 have been isolated from the berries of Phytolacca dodecandra L'HERIT (Phytolaccaceae).The structures have been established by spectroscopic ((1)H-NMR, (13)C-NMR, FAB-MS, DCI-MS, and GC/MS) and chemical methods (acid, basic, and enzymatic hydrolysis).Saponins 1 and 3 are tetra- and pentaglycosides of oleanolic acid, whereas 2 is a tetraglycoside of bayogenin.The corresponding prosapogenins 1a-3a, obtained by cleavage of a glucose unit esterified at C(28), exhibited strong molluscicidal activity against schistosomiasis-transmitting snails.
- Dorsaz, Anne-Christine,Hostettmann, Kurt
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p. 2038 - 2047
(2007/10/02)
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- New Saponins from Phytolacca dodecandra l'Herit
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Three bidesmosidic saponins (1-3) have been isolated from the methanolic extract of the berries of Phytolacca dodecandra l'Herit (Phytolaccaceae) by a combination of rotation locular counter-current chromatography and column chromatography on reversed phase (RP-8) with MeOH/H2O.The structures have been established by 1H-NMR, 13C-NMR, FAB-MS, and D/Cl-MS, as well as on the basis of acidic and basic hydrolyses.The monodesmosidic saponins 1a-3a obtained after partial hydrolysis with a base exhibit strong molluscicidal activity against the schistosomiasis-transmitting snail Biomphalaria glabrata.Saponins 1-3, 1a, and 3a are reported for the first time, whereas 2a has been identified previously in the aqueous extract of P. dodecandra berries.
- Domon, Bruno,Hostettmann, Kurt
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p. 1310 - 1315
(2007/10/02)
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- The Separation of Substituted Olean-12-en-28-oic Acids from the Corresponding Urs-12-en-28-oic Acid Isomers
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Naturally occurring pairs of hydroxy-substitutent olean-12-en-28-oic and urs-12-en-28-oic acids may be separated by treatment of the mixture with bromide in acetic acid.Members of the ursene family are inert under the conditions used.It is shown that a similar separation is possible with the 12-en-28-ol system.The leaf of Duboisia myoporoides was examined for possible variation of ursolic acid content with location.
- Lewis, Keith G.,Tucker, David J.
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p. 2297 - 2306
(2007/10/02)
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