- PROCESS FOR PREPARATION OF OPTICALLY ENRICHED ALDOL COMPOUNDS
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The present invention relates to a process for preparing benzylic amidesof formula (I) wherein the variables are as defined in the specification, and the shown enantiomer has at least 50 % ee; by condensation of a ketone o formula (II) with an acetyl compound of formula (III) in the presence of a catalystof formula (IV) wherein the variables are as defined in the specification.
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Page/Page column 26
(2020/05/28)
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- Design and synthesis of sarolaner, a novel, once-a-month, oral isoxazoline for the control of fleas and ticks on dogs
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Over the last decade, the isoxazoline motif has become the intense focus of crop protection and animal health companies in their search for novel pesticides and ectoparasiticides. Herein we report the discovery of sarolaner, a proprietary, optimized-for-animal health use isoxazoline, for once-a-month oral treatment of flea and tick infestation on dogs.
- Curtis, Michael P.,Vaillancourt, Valerie,Goodwin, Richard M.,Chubb, Nathan A.L.,Howson, William,McTier, Tom L.,Pullins, Aleah,Zinser, Erich W.,Meeus, Patrick F.M.,Woods, Debra J.,Hedges, Laura,Stuk, Tim,Price, Jeffrey E.,Koch, Jason D.,Menon, Sanjay R.
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p. 1831 - 1835
(2016/12/22)
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- CRYSTALLINE FORMS OF 1-(5'-(5-(3,5-DICHLORO-4-FLUOROPHENYL)-5-(TRIFLUOROMETHYL)-4,5-DIHYDROISOXAZOL-3-YL)-3'H-SPIRO[AZETIDINE-3,1'-ISOBENZOFURAN]-1-YL)-2-(METHYLSULFONYL)ETHANONE
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The present invention relates to novel crystalline modifications of 1-(5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran]-1-yl)-2-(methylsulfonyl)ethanone. The present invention also describes compositions and methods of treating a parasitic infection or infestation in an animal in need thereof. The present invention also relates to processes for making the crystalline forms.
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Page/Page column 49
(2014/03/25)
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- SPIROCYCLIC ISOXAZOLINE DERIVATIVES FOR TREATMENT OF SEA LICE
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The invention recites a method of treating a parasitic infection in fish comprising administering an effective amount of a spirocyclic isoxazoline compound of Formula 1, stereoisomers thereof, and veterinary acceptable salts thereof, for use against sea lice in a fish, and compositions thereof, (formula I), wherein W, X, R1a, R1b, R1c, R2, R3, R4, n, and * are as defined herein.
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Page/Page column 35
(2014/03/26)
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- SPIROCYCLIC ISOXAZOLINE DERIVATIVES AS ANTIPARASITIC AGENTS
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The invention recites spirocyclic isoxazoline derivatives of Formula (V.1), Formula (V.2), Formula (V.1.1), and Formula (1) stereoisomers thereof, veterinarily acceptable salts thereof, compositions thereof, processes for making, and their use as a parasi
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