Facile preparation of highly-functionalized, nitrogen-bearing diarylmethanes
A palladium-catalyzed cross coupling of nitrogen bearing heterocyclic chloromethyl derivatives with aryl and heteroaryl boronic acids has been developed. In almost all cases, highly efficient cross-couplings were observed at ambient temperature, mitigating unwanted thermally induced side-reactions. The comprehensive substrate scope and respectable yields highlight the synthetic utility of this reaction.
Schmink, Jason R.,Tudge, Matthew T.
p. 15 - 20
(2013/02/21)
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