Synthesis of phenanthridine derivatives by microwave-mediated cyclization of o-furyl(allylamino)arenes
A novel and efficient synthesis of phenanthridines and aza analogues is reported. The key step is a microwave-mediated intramolecular Diels-Alder cyclization of o-furyl(allylamino)arenes. In the presence of a catalytic amount of acid, the DA-adduct reacts further to give the dihydrophenanthridines, which easily can be oxidized to fully aromatic compounds by air in the presence of UV light or by DDQ.
Read, Matthew Lovell,Gundersen, Lise-Lotte
p. 1311 - 1316
(2013/03/29)
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