- Modular Solid-Phase Synthesis of Antiprotozoal Barnesin Derivatives
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Here, we applied and optimized a solid support (SP)-based Horner-Wadsworth-Emmons reagent to prepare SP-bound vinylogous amino acids. Subsequent SP-based peptide synthesis, global deprotection, and chemical modifications yielded 14 lipodipeptides carrying
- Roman, Dávid,Ragu?, Luka,Keiff, Fran?ois,Meyer, Florian,Barthels, Fabian,Schirmeister, Tanja,Kloss, Florian,Beemelmanns, Christine
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supporting information
p. 3744 - 3748
(2020/04/02)
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- An efficient and economical method for the preparation of Fmoc-Arg ωω (Boc) 2-OH
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The arginine derivative Fmoc-Arg omega;ω″(Boc) 2-OH has been prepared in perfect yield starting from Fmoc-Orn?HCl and N,N′-di-Boc-N″-triflyguanidine with the presence of diisopropylethylamine (DIEA). This work provides an efficient a
- Zhu, Ruixin,Xie, Ming,Wang, Fei,Liu, Qi,Kang, Tingguo
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experimental part
p. 1508 - 1509
(2011/01/04)
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- Miraziridine A: Natures blueprint towards protease class-spanning inhibitors
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The natural product miraziridine A isolated from the marine sponge Theonella aff. mirabilis unifies within one molecule three structurally privileged elements: (i) (2R,3R)-aziridine-2,3-dicarboxylic acid, (ii) (3S,4S)-4-amino-3-hydroxy-6-methylheptanoic acid (statine), and (iii) (E)-(S)-4-amino-7-guanidino-hept-2-enoic acid (vinylogous arginine). The alignment of them realized in the tetrapetide allows for a simultaneous inhibition of the proteolytic activity of trypsin-like serine proteases, papain-like cysteine proteases, and pepsin-like aspartyl proteases. Therefore, this unique compound represents a blueprint for the design of protease class-spanning inhibitors.
- Schaschke, Norbert
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p. 855 - 857
(2007/10/03)
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- A facile preparation of Fmoc-Argω,ω′(Boc)2 -OH and Z-Argω,ω′ (Boc)2 -OH, new arginine derivatives for peptide synthesis
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The new arginine derivatives Fmoc-Argω,ω′(Boc)2 -OH and Z-Argω,ω′ (Boc)2 -OH have been easily prepared in hiqh yield starting from Z-Orn-OH and N,N′-bis (tert-butoxycarbonyl) -S-methylisothiourea.
- Verdini, Antonio S.,Lucietto, Pierluigi,Fossati, Gianluca,Giordani, Cristiana
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p. 6541 - 6542
(2007/10/02)
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