- DRUGS, FOOD OR DRINK FOR IMPROVING PANCREATIC FUNCTIONS
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Compounds having a cyclolanostane skeleton such as 9,19-cyclolanostan-3-ol and 24-methylene-9,19-cyclolanostan-3-ol are used as an active ingredient of a drug and food or drink for improving pancreatic functions.
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Page/Page column 14
(2008/06/13)
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- Inhibitory effect of cycloartenol ferulate, a component of rice bran, on tumor promotion in two-stage carcinogenesis in mouse skin
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Inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)- induced inflammation in mice was observed in the methanol extract of rice bran and γ-oryzanol. The active components of rice bran, sitosterol ferulate, 24-methylcholesterol ferulate, cycloartenol ferulate and 24- methylenecycloartanol ferulate inhibited markedly the TPA-induced inflammation in mice. The 50% inhibitory dose of these compounds for TPA- induced inflammation was 0.2-0.3 mg/ear. Furthermore, cycloartenol ferulate markedly inhibited the tumor-promoting effect of TPA in 7,12- dimethylbenz[α]lanthracene-initiated mice.
- Yasukawa, Ken,Akihisa, Toshihiro,Kimura, Yumiko,Tamura, Toshitake,Takido, Michio
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p. 1072 - 1076
(2007/10/03)
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- Conformational Analysis of Cycloartenol, 24-Methylenecycloartanol and Their Derivatives
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A conformational analysis of cycloartenol, 24-methylenecycloartenol and their derivatives was carried out in the solution and the solid state by an NMR study and X-ray crystallographic analysis, respectively.Complete assignments of the 1H NMR spectra of these compounds were made in order to elucidate the conformation involving the ring system and side chain.Rings A to C had a chair-halfchair-boat conformation, and the side chain had a zig-zag conformation.
- Yoshida, Kumi,Hirose, Yoshihiko,Imai, Yutaka,Kondo, Tadao
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p. 1901 - 1912
(2007/10/02)
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- 7-OXO-24ξ(28)-DIHYDROCYCLOEUCALENOL, A POTENT INHIBITOR OF PLANT STEROL BIOSYNTHESIS
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Cycloeucalenol-obtusifoliol isomerase from higher plant cells catalyses the opening of the cyclopropane ring of cycloeucalenol yielding obtusifoliol. 7-Oxo-24ξ(28)-dihydrocycloeucalenol was not a substrate but behaved like a potent inhibitor of the isomerase.The inhibition was reversible and highly specific; the inhibitor needed the presence of the 7-oxo group, the cyclopropane ring and the absence of a 4β-methyl group to be active.Other enzymes involved in plant sterol biosynthesis such as 2,3-oxidosqualene-cycloartenol cyclase and S-adenosyl methionine cycloartenol C-24 methyltransferase were not inhbited by 7-oxo-24ξ(28)-dihydrocycloeucalenol.In vivo treatment of a suspension of bramble cells growing in a liquid medium with 7-oxo-24ξ(28)-dihydrocycloeucalenol resulted in a strong accumulation of 9β,19-cyclopropyl sterols confirming that the main cellular target of the inhibitor is the cycloeucalenol-obtusfoliol isomerase.Key Word Index - Zea mays; Gramineae; Rubus fruticosus; Rosaceae; plant sterol biosynthesis inhibitors; cycloeucalenol-obtusifoliol isomerase; 7-oxo-24ξ(28)-dihydrocycloeucalenol; cellular and enzymatic targets at 7-oxo-24ξ(28)-dihydrocycloeucalenol.
- Rahier, Alain,Schmitt, Paulette,Benveniste, Pierre
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p. 1969 - 1974
(2007/10/02)
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