Demethylation reactions of 4-amino-N-(2,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide (sulfadimethoxine) in strongly basic aqueous solution
Hydrolysis of 1 in strongly basic aqueous solution afforded mono- and didemethylated products 2, 3 and 4, that are postulated as the metabolites of 1 in some animals. This hydrolytic demethylation was shown to proceed stepwise via mono-demethylation to gi
Miura,Ono,Yoshida,Kato,Yoshioka,Tachi,Eguchi
p. 1407 - 1411
(2007/10/02)
ALKALINE HYDROLYSIS OF DIAZINE SULFANILAMIDES CONTAINING A METHOXY GROUP
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Skachilova, S. Ya.,Shramova, Z. I.,Voronin, V. G.,Petrugova, N. P.,Ermakova, G. A.,et al.
p. 810 - 812
(2007/10/02)
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