14762-26-6Relevant articles and documents
Demethylation reactions of 4-amino-N-(2,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide (sulfadimethoxine) in strongly basic aqueous solution
Miura,Ono,Yoshida,Kato,Yoshioka,Tachi,Eguchi
, p. 1407 - 1411 (2007/10/02)
Hydrolysis of 1 in strongly basic aqueous solution afforded mono- and didemethylated products 2, 3 and 4, that are postulated as the metabolites of 1 in some animals. This hydrolytic demethylation was shown to proceed stepwise via mono-demethylation to gi