1220-83-3 Usage
Description
Sulfamonomethoxine is a synthetic antimicrobial agent that belongs to the sulfonamide class of drugs. It is characterized by its white to off-white crystalline powder form and possesses protein binding properties. Sulfamonomethoxine works by inhibiting bacterial enzymes, specifically dihydropteroate synthase, which is essential for the synthesis of folic acid in bacteria. This inhibition disrupts the bacterial cell's ability to produce essential components, ultimately leading to its death.
Uses
1. Used in Pharmaceutical Industry:
Sulfamonomethoxine is used as an antimicrobial agent for treating various bacterial infections. Its application is based on its ability to inhibit bacterial enzyme activity, thus preventing the growth and proliferation of harmful bacteria.
2. Used in Veterinary Medicine:
Sulfamonomethoxine is used as a veterinary drug for treating porcine unknown hyperpyrexia, a severe, high fever in pigs. The application is due to its effectiveness in combating bacterial infections that may cause this condition.
3. Used in Combination Therapy:
Sulfamonomethoxine is often used in combination with Trimethoprim, another antimicrobial agent. This combination enhances the overall efficacy of the treatment by targeting different stages of bacterial enzyme inhibition. The synergistic effect of these two drugs helps in achieving a more potent and rapid response against bacterial infections.
4. Used in Enzyme Inhibition Studies:
Sulfamonomethoxine is also utilized in research and development as an inhibitor of bacterial enzymes. Its application in this context is to study the effects of enzyme inhibition on bacterial growth and to develop new strategies for combating antibiotic-resistant bacteria.
Synthesis Reference(s)
The Journal of Organic Chemistry, 26, p. 2764, 1961 DOI: 10.1021/jo01066a034
Biochem/physiol Actions
Sulfamonomethoxine is a competitive inhibitor of dihydropteroate synthetase used to block the synthesis of folic acid.
Check Digit Verification of cas no
The CAS Registry Mumber 1220-83-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,2,2 and 0 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1220-83:
(6*1)+(5*2)+(4*2)+(3*0)+(2*8)+(1*3)=43
43 % 10 = 3
So 1220-83-3 is a valid CAS Registry Number.
InChI:InChI=1/C11H12N4O3S/c1-18-11-6-10(13-7-14-11)15-19(16,17)9-4-2-8(12)3-5-9/h2-7H,12H2,1H3,(H,13,14,15)