- Taxanes having an alkyl substituted side-chain and pharmaceutical compositions containing them
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Taxane derivatives having an alkyl substituted C13 side chain.
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Page column 25
(2010/01/30)
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- C13 amido substituted taxane derivatives and pharmaceutical compositions containing them
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Taxane derivatives having an amino substituted C13 side chain.
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Page column 25
(2010/01/31)
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- An efficient semisynthesis of 7-deoxypaclitaxel from taxine
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A semisynthesis of 7-deoxypaclitaxel 4 is described, starting from taxine 6 - the most abundant naturally occurring taxane diterpene fraction. A key step in this transformation is a tandem reaction: stereoselective osmylation of cinnamic ester 14/intramolecularly assisted methanolysis of 16, which gives the key intermediate 5, along with the optically pure ester 17 - a precursor for the synthesis of the paclitaxel side-chain. In this way, the cinnamoyltaxicine 9 is converted into 7-deoxybaccatin III 25 in 11 steps, and in 15% overall yield.
- Saicic, Radomir N.,Matovic, Radomir
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- An efficient semisynthesis of 7-deoxypaclitaxel from taxine
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Highly cytotoxic 7-deoxypaclitaxel analogues are obtained by a semisynthesis starting from taxine - the most abundant naturally occurring taxane diterpene fraction.
- Matovic, Radomir,Saicic, Radomir N.
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p. 1745 - 1746
(2007/10/03)
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- Taxoids: 7-Deoxy-10-acetyldocetaxel and new analogs prepared from the yew tree alkaloids
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Three new 7-deoxydocetaxel derivatives have been prepared from natural taxine B and isotaxine B: the first one, 2-debenzoyl-9-dihydro-1,2-O-benzylidine-9,10-O-isopropylidene-7-deoxydocetaxel has a slight cytotoxicity and a weak microtubule disassembly inhibitory activity; the other two derivatives, 9-dihydro-9,10-O-isopropylidene-7-deoxydocetaxel and 7-deoxy-10-acetyldocetaxel are cytotoxic and reveal a good microtubule disassembly inhibitory activity.
- Poujol, Helene,Al Mourabit, Ali,Ahond, Alain,Poupat, Christiane,Potier, Pierre
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p. 12575 - 12594
(2007/10/03)
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- Synthesis of 7-Deoxy- and 7,10-Dideoxytaxol via Radical Intermediates
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7-Deoxytaxol and 7,10-dideoxytaxol were prepared from baccatin III, employing the Barton deoxygenation procedure and the Holton acylation method at C-13.
- Chen, Shu-Hui,Huang, Stella,Kant, Joydeep,Fairchild, Craig,Wei, Jianmei,Farina, Vittorio
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p. 5028 - 5029
(2007/10/02)
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