A facile synthesis of 7,10-dideoxy taxol and 7-epi-10-deoxy taxol
7,10-Dideoxy taxol 2 was prepared from baccatin III in 4 steps via the Barton deoxygenation reaction. Similarly, 7-epi-10-deoxy taxol 3 was prepared in one step from 7-epi taxol in high yield. The key reaction was the tributyltin hydride-mediated directed reduction of the C10 acetate.
Taxanes having an alkyl substituted side-chain and pharmaceutical compositions containing them
Taxane derivatives having an alkyl substituted C13 side chain.
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Page column 25
(2010/01/30)
C2 substituted phenyl taxane derivatives and pharmaceutical compositions containing them
Taxane derivatives having alternative C2 substituents.
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Page column 25
(2010/01/30)
C13 amido substituted taxane derivatives and pharmaceutical compositions containing them
Taxane derivatives having an amino substituted C13 side chain.
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Page column 24-25
(2010/01/31)
Studies on the photochemistry of taxol
Irradiation of taxol at 280 nm in a Rayonet reactor yielded a novel pentacyclic derivative containing a new bond between C-3 and C-11. The proposed mechanism involves a triplet intermediate and the first event of the oxa-di-π-methane rearrangement. Taxane
Chen,Farina,Huang,Gao,Golik,Doyle
p. 8633 - 8650
(2007/10/02)
Synthesis of 7-Deoxy- and 7,10-Dideoxytaxol via Radical Intermediates
7-Deoxytaxol and 7,10-dideoxytaxol were prepared from baccatin III, employing the Barton deoxygenation procedure and the Holton acylation method at C-13.