A facile synthesis of 7,10-dideoxy taxol and 7-epi-10-deoxy taxol
7,10-Dideoxy taxol 2 was prepared from baccatin III in 4 steps via the Barton deoxygenation reaction. Similarly, 7-epi-10-deoxy taxol 3 was prepared in one step from 7-epi taxol in high yield. The key reaction was the tributyltin hydride-mediated directed reduction of the C10 acetate.
Chen,Wei,Vyas,Doyle,Farina
p. 6845 - 6848
(2007/10/02)
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