- Silver-Catalyzed C(sp3)-H Chlorination
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A silver-catalyzed chlorination of benzylic, tertiary, and secondary C(sp3)-H bonds was developed. The reaction proceeded with as low as 0.2 mol % catalyst loading at room temperature under air atmosphere with synthetically useful functional group compatibility. The regioselectivity and reactivity tendencies suggest that the chlorination proceeded through a radical pathway, but an intermediate alkylsilver species cannot be ruled out.
- Ozawa, Jun,Kanai, Motomu
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supporting information
p. 1430 - 1433
(2017/03/23)
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- Crucial role of selenium in the virucidal activity of benzisoselenazol- 3(2h)-ones and related diselenides
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Various N-substituted benzisoselenazol-3(2H)-ones and their non-seleniumcontaining analogues have been synthesized and tested against selected viruses (HHV-1, EMCV and VSV) to determine the extent to which selenium plays a role in antiviral activity. The data presented here show that the presence of selenium is crucial for the antiviral properties of benzisoselenazol-3(2H)-ones since their isostructural analogues having different groups but lacking selenium either did not show any antiviral activity or their activity was substantially lower. The open-chain analogues of benzisoselenazol- 3(2H)-ones-diselenides also exhibited high antiviral activity while selenides and disulfides were completely inactive towards model viruses.
- Pietka-Ottlik, Magdalena,Potaczek, Piotr,Piasecki, Egbert,Mlochowski, Jacek
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experimental part
p. 8214 - 8228
(2011/03/19)
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- Process for preparing o-(carboalkoxy)phenylmethanesulfonyl chloride derivatives
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A process for preparing an o-(carboalkoxy)phenylmethanesulfonyl chloride derivative of formula (1), wherein: X is chosen from a hydrogen atom, halogen atoms, C1to C6alkyl groups, C1to C6haloalkyl groups, C1to C6alkoxy groups, C1to C6alkoxycarbonyl groups, a nitro group, and a phenyl group; R is chosen from C1to C6alkyl groups, C1to C6haloalkyl groups, and C3to C6cycloalkyl groups; and n is chosen from integers ranging from 1 to 4, is discussed.
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- Generation and Thermal Reactions of 2-Methyl-4-oxo-2-selenoniochroman-3-ide
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The thermal reaction of 2-methyl-4-oxo-2-selenoniochroman-3-ide (4) in aprotic solvents afforded (E)-bisbenzoyl>ethylene (5) and trans-1,2,3-trisbenzoyl>cyclopropane (6) via a carbene intermediate.Ethanol reacted thermally with 4 to open the chroman ring, giving ethyl 2-benzoate (9a) and ethyl 2-(ethoxymethyl)benzoate (10a), whereas reaction with methanol yielded only methyl 2-benzoate (9b).Hydrolysis of ylide 4 eliminated dimethyl selenide, giving phthalide and 2-(hydroxymethyl)benzoic acid.
- Hori, Mikio,Kataoka, Tadashi,Shimizu, Hiroshi,Tsutsumi, Kazuhiro
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p. 1397 - 1400
(2007/10/02)
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