Synthesis of Benzo-Fused Benzodiazepines Employed as Probes of the Agonist Pharmacophore of Benzodiazepine Receptors
The synthesis and in vitro evaluation of benzo-fused benzodiazepines 1-6 are described.These "molecular yardsticks" were employed to probe the spatial dimensions of the lipophilic pocket L2 in the benzodiazepine receptor (BzR) cleft and to dete
Zhang, Weijiang,Koehler, Konrad F.,Harris, Bradford,Skolnick, Phil,Cook, James M.
p. 745 - 757
(2007/10/02)
The Regiospecific Synthesis Of Ortho Aminonaphthophenones Via The Addition Of Carbanions To Naphthoxazin-4-Ones
The conversion of nitronaphthalenes (see 4a and 4b) into the corresponding ortho aminonaphthylnitriles (5a and 5b) via the process of Tomioka, when combined with the addition of carbanions to the intermediate naphthoxazin-4-ones, provided a route to ortho aminonaphthophenones (7a) and (7b).These key intermediates were employed to synthesize the benzfused 2'-fluoro-1,4-benzodiazepines (1-3).
Zhang, Weijiang,Liu, Ruiyan,Cook, James M.
p. 2229 - 2236
(2007/10/02)
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