- Three Ways Aliphatic Aldehydes React with Nonstabilized Azomethine Ylides
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Aliphatic aldehydes readily react with nonstabilized azomethine ylides in one of the three ways to give oxazolidines, pyrrolidines, or Mannich bases, depending on the structure of the starting compound and the reaction conditions. The use of N -(methoxymethyl)- N -[(trimethylsilyl)methyl]benzylamine in DMF provided 5-alkyloxazolidines in 40-97percent yields. On the other hand, three-component reactions of aliphatic aldehydes bearing one α-hydrogen with N -methyl(benzyl)glycine and formaldehyde gives Mannich bases in yields of 47-98percent. A similar reaction of aldehydes bearing branched alkyl groups and two hydrogen atoms at the α-position proceeds as a domino process that gives 3-alkyl-3-formylpyrrolidines in yields of 34-93percent.
- Buev, Evgeny M.,Gorbunova, Evgeniya V.,Moshkin, Vladimir S.,Sosnovskikh, Vyacheslav Y.
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supporting information
p. 343 - 348
(2020/02/27)
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- A polyamine with aliphatic sec
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Polyamine compound (I) is new. Polyamine compound of formula A(NHCH 2CR1R2CH(R3)NR5R4) a(I) is new. A : primary amino, secondary amino, OH or mercapto (if a = 1) or amine group after removing primary aliphatic amino group; R1, R2 : monovalent 1-12C hydrocarbyl; or R1+R2 : divalent 4-12C hydrocarbyl (which is a part of 5-8C, preferably 6C carbocyclyl (optionally substituted)); R3 : H, (aryl)alkyl or alkoxycarbonyl; either R4 : 1-20C (cyclo)aliphatic or 1-20C aryl-aliphatic (both monovalent and optionally contains heteroatoms); and R5 : R4 or H; or R4+R5 : divalent 3-30C aliphatic group (which is a part of heterocyclyl with 5-8, preferably 6 ring atoms (optionally substituted and optionally contains further hetero atoms adjacent to N)); and a : 1-6. Independent claims are also included for: (1) preparing (I); (2) an adduct obtained by reacting (I) with at least one compound carrying at least one, preferably at least two reactive groups, preferably isocyanate-, isothiocyanate-, cyclocarbonate-, epoxide-, episulfide-, aziridine-, acryl-, methacryl-, 1-ethynyl carbonyl-, 1-propynyl carbonyl-, maleimide-, citraconimide-, vinyl-, isopropenyl- or allyl groups; (3) an isocyanate groups exhibiting composition comprising (a) at least one polyisocyanate, and (b) at least one hardener compound exhibiting at least two reactive groups, preferably primary amino-, secondary amino-, hydroxyl- or mercapto groups, where the polyisocyanate and/or the hardener compound comprises (I), a propanediamine derivative of formula (-NH-CH 2-C(R1)(R2)-CH(R3)-N(R4)-R5) (VIII) or at least two isocyanate groups exhibiting adduct; (4) a cured composition (i) obtained by reacting at least one polyisocyanate with at least one hardener compound of the above isocyanate groups exhibiting composition; (5) an epoxy resin composition comprising at least one epoxy resin, and (I); and (6) a cured composition (ii) obtained by reacting at least one epoxy resin with (I).
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Paragraph 0302; 0305-0306
(2016/10/08)
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- SECONDARY AMINOSILANES
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The present disclosure invention relates to novel secondary aminosilanes, a method for producing same, and the use thereof. The secondary aminosilanes can be produced from readily available reactants in a simple manner. The secondary aminosilanes are characterized for example by a low viscosity and are well suited for producing silane-functional polymers that have a low viscosity, fast curing, and good thermal stability.
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Paragraph 0238; 0239
(2013/11/05)
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- N-hydroxyformamidine derivatives
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An N-hydroxyformamidine derivative of the following formula or a pharmaceutically acceptable salt thereof: (wherein R1 represents a hydrogen atom, a C1-4 alkyl group, a C1-4 alkoxy group or a halogen atom, A represents a C1-10 alkylene group or a group of the following formula: (wherein m, n and p each represent an integer of 0 to 4), and R represents an N,N-di-C1-6 alkylamino group, a dioxanyl group, a C1-4 alkyl-substituted dioxanyl group, a C1-4 alkoxy-C1-4 alkoxy group or a group of the following formula: (wherein s and t each represent an integer of 1 to 4, B represents a methylene group, an oxygen atom, a sulfur atom, a nitrogen atom, a C1-4 alkyl-substituted nitrogen atom, a phenyl-substituted nitrogen atom or a benzyl-substituted nitrogen atom, R2 represents a hydrogen atom or a C1-4 alkyl group, and r represents an integer of 0 to 2)). The present invention aims to provide an agent for inhibiting 20-HETE-producing enzymes, 20-HETE being involved in the effects of causing microvascular constriction or dilation in major organs (e.g., kidneys, cerebral blood vessels) or of inducing cell proliferation, etc.
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Page/Page column 5
(2010/02/15)
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- Seven-Membered Rings by 1,5-Cycloadditions, VI. - 7-Aminoperhydro-1,4-oxazepines and -diazepines
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3-Alkyl-1,3-oxazolidines 2 react with enamines 1 in the presence of trifluoroacetic acid to give 7-dialkylaminoperhydro-1,4-oxazepines 3. 1,3-Dimethyl-1,3-imidazolidine (2d) reacts with 4-(2-methyl-1-propenyl)morpholine (1a) to give 1,4,6,6-tetramethyl-7-morpholino-2,3,4,5,6,7-hexahydro-1H-1,4-diazepine (3m).
- Griengl, Herfried,Prischl, Gerhard,Bleikolm, Anton
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p. 1573 - 1582
(2007/10/02)
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