- Preparation method of 2-chloro-4-nitrobenzene-alpha-L-fucoside
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The invention discloses a preparation method of 2-chloro-4-nitrobenzene-alpha-L-fucoside, and belongs to the field of in vitro diagnosis. The preparation method comprises the following steps: taking L-fucose as an initial raw material, carrying out acetylation reaction to prepare 1, 2, 3, 4-tetraacetyl-alpha-L-fucose, and then carrying out glycosylation reaction on the 1, 2, 3, 4-tetraacetyl-alpha-L-fucose and 2-chloro-4-nitrophenol to prepare the 2-chloro-4-nitrobenzene-2, 3, 4-triacetyl-alpha-L-fucoside, the catalyst is selected from Trimethylsilyl trifluoromethanesulfonate or Boron trifluoride ethyl ether; and finally, carrying out a deacetylation reaction, so as to prepare the 2-chloro-4-nitrobenzene-alpha-L-fucoside. The method disclosed by the invention is relatively short in reaction route, and the final product is prepared through three-step reaction; L-fucose is used as the raw material, the price of the initial raw material is relatively low, and the dosage of 2-chloro-4-nitrophenol is obviously reduced; the post-treatment process is simple, the reaction reproducibility is good, and industrial production can be realized.
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Paragraph 0009; 0033; 0038-0039; 0042; 0047-0048; 0050; ...
(2021/10/11)
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- Synthesis of 2-chloro-4-nitrophenyl α-L-fucopyranoside: A substrate for α-L-fucosidase (AFU)
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An effective method to prepare the substrate of α-L-fucosidase (AFU) is described. Ethyl 1-thiofucoside with a free 2-OH group was used as the glycosyl donor, and there was found no self-condensed side product. The use of the HF·pyridine reagent to remove
- Gu, Guofeng,Du, Yuguo,Hu, Hongyan,Jin, Cheng
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p. 1603 - 1607
(2007/10/03)
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