- Preparation method of diethyl cromoglycate and sodium cromoglycate
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The invention relates to the technical field of medicines, in particular to a preparation method of diethyl cromoglycate and sodium cromoglycate. The preparation method comprises the following steps:reacting 2, 6-dihydroxy acetophenone with diethyl oxalate to obtain 7-hydroxy-4-oxo-4H-benzopyran-2-carboxylic acid ethyl ester, and then reacting with 1, 3-dibromo-2-propanol(or epoxy chloropropane)to prepare diethyl cromoglycinate, because one phenolic hydroxyl group in the 7-hydroxy-4-oxo-4H-benzopyran-2-carboxylic acid ethyl ester molecule is protected, cutting off the source of polymolecularpolycondensation reaction, wherein two reaction sites of 1, 3-dibromo-2-propanol(or epoxy chloropropane) need to participate in the reaction, and obtaining the unique product diethyl cromoglycate through the reaction. Therefore, the yield of the diethyl cromoglycate is very high.
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Paragraph 0072; 0080-0085; 0087-0088; 0090-0091; 0093-0094
(2021/02/20)
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- Synthesis of nitric acid esters from alcohols in a dinitrogen pentoxide/carbon dioxide liquid system
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Organic nitric acid esters have been prepared in 89-98% yield by the nitration of the corresponding alcohols and polyols with N2O5 in liquid CO2.
- Kuchurov, Ilya V.,Fomenkov, Igor V.,Zlotin, Sergei G.,Tartakovsky, Vladimir A.
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experimental part
p. 67 - 69
(2012/07/02)
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- HYDROGEL CONTACT LENS FOR SUSTAINED DRUG RELEASE AND DRUG RELEASE METHOD USING HYDROGEL CONTACT LENS FOR SUSTAINED DRUG RELEASE
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Disclosed is a sustainedly drug-releasing hydrogel contact lens which can sustainedly release an anionic medicament such as an allergy-treating agent in a mildly irritating and effective manner while achieving vision correction. Specifically disclosed is a hydrogel comprising ionic monomers composed of at least a cationic monomer and an anionic monomer, wherein the component ratio of the ionic monomers is 5 to 20 mol % inclusive relative to the total amount of monomers that constitute the gel, and the content of the anionic monomer is 15 to 25 mol % inclusive relative to the content of the cationic monomer.
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- Clear, stable cromolyn formulation
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A substantially clear, sterile, aqueous tonicity adjusted composition of 1,3-bis(2-carboxychromon-5-yloxy)propan-2--ol, other bis-cromolyn derivatives, or pharmaceutically acceptable salts thereof, is provided which contains over 20 ppm transition metal ions or ions of Group IIA, IB, IIB or IV B. The composition is useful as an anti-inflammatory agent in the treatment of bronchial asthmatics and allergic or immune reactions in the eye and nose.
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- Method of treating atopic eczema
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The present invention relates to methods of treating chronic skin disorders by externally applying to the skin compounds by the following formula STR1 and therapeutically acceptable salts, esters and amides thereof, wherein R1 through R6 and X are as hereinafter defined.
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- Pharmaceutical composition and process of treatment
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A process for alleviating proliferative skin diseases such as psoriasis, atopic dermatitis, etc. comprising administering to humans, or domesticated animals, topically and/or systemically a composition comprising a pharmaceutical carrier and at least one active compound selected from the groups, substituted alkyl zanthines, tricyclic antidepressants, organic nitrates, antihypertensives, anti-asthma agents and central nervous system depressants and combinations of certain compounds from specifically named groups of compounds.
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