CAS No.15826-37-6,Sodium cromoglycate Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	15826-37-6
Name:	Sodium cromoglycate
Article Data:	25

Formula:	C₂₃H₁₄Na₂O₁₁
Molecular Weight:	512.337
Synonyms:	Aarane;Allergocrom;Altoderm;Colimune;Cromolyn disodium salt;Cromovet;DSCG;Disodium 1,3-bis(2-carboxy-5-chromonyloxy)-2-propanol;Disodium chromoglycate;
EINECS:	239-926-7
Melting Point:	241-242 °C
Boiling Point:	752.3 °C at 760 mmHg
Flash Point:	263.9 °C
Solubility:	Soluble in water to 100mg/ml
Appearance:	white crystalline powder
Hazard Symbols:	Xi
Risk Codes:	36/37/38
Safety:	26-36
PSA:	179.37000
LogP:	-0.55490

Synthetic route

: 16150-45-1
1,3-bis(2-carboethoxychromon-5-yloxy)-2-hydroxypropane

: 15826-37-6
disodium cromoglicate

Conditions

Conditions	Yield
With sodium hydroxide In ethanol; water at 65℃; for 5h; Temperature;	97.1%

: methacrylamide propyl trimethyl ammonium chloride

: 923-26-2
2-hydroxypropyl methacrylate

: 97-90-5
EDMA

methacryloxyethyl succinic acid: methacryloxyethyl succinic acid

: 15826-37-6
disodium cromoglicate

Conditions

Conditions	Yield
With azobisisobutyronitrile; nitrogen
With azobisisobutyronitrile; nitrogen
With azobisisobutyronitrile; nitrogen

...Expand

: 699-83-2
2,6-dihydroxylacetophenone

: 15826-37-6
disodium cromoglicate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: sodium ethanolate / ethanol / 10 h / 60 °C 2: isopropyl alcohol / 10 h / 100 °C 3: sodium hydroxide / ethanol; water / 5 h / 65 °C View Scheme
Multi-step reaction with 3 steps 1: sodium ethanolate / ethanol / 10 h / 60 °C 2: isopropyl alcohol / 6 h / 75 °C 3: sodium hydroxide / ethanol; water / 5 h / 65 °C View Scheme

: 50521-64-7
5-hydroxy-4-oxo-4H-benzopyran-2-carboxylic acid ethyl ester

: 15826-37-6
disodium cromoglicate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: isopropyl alcohol / 10 h / 100 °C 2: sodium hydroxide / ethanol; water / 5 h / 65 °C View Scheme

: 64-17-5
ethanol

: 15826-37-6
disodium cromoglicate

: 16150-45-1
1,3-bis(2-carboethoxychromon-5-yloxy)-2-hydroxypropane

Conditions

Conditions	Yield
With hydrogenchloride at 95 - 100℃; for 28h; Inert atmosphere;	80%
With hydrogenchloride In water at 100℃; for 24h; Sealed tube;	76%
With hydrogenchloride In water at 100℃; for 24h; Sealed tube;	76%

: 15826-37-6
disodium cromoglicate

: disodium cromoglycate-3,3'-d2

Conditions

Conditions	Yield
With rhodium(III) chloride; water-d2 In N,N-dimethyl-formamide at 108℃;	77%

: 15826-37-6
disodium cromoglicate

: 16110-51-3
cromoglicinic acid

Conditions

Conditions	Yield
With hydrogenchloride In water pH=3;	66%
With hydrogenchloride In water pH=3;	66%
With hydrogenchloride In water at 20℃; pH=2;

: 15826-37-6
disodium cromoglicate

: 16150-44-0
(1-{2-[3-(2-acetyl-3-hydroxy-phenoxy)-2-hydroxypropoxy]-6-hydroxy-phenyl}-ethanone)

Conditions

Conditions	Yield
With sodium hydroxide for 0.333333h; Heating;	59.7%
With potassium hydroxide In water for 2h; Reflux;

: 15826-37-6
disodium cromoglicate

: 92588-95-9
C23H12(3)H2O11(2-)*2Na(1+)

Conditions

Conditions	Yield
With rhodium(III) chloride; tritium oxide In N,N-dimethyl-formamide at 108℃;

: 15826-37-6
disodium cromoglicate

: 75-03-6
ethyl iodide

: 16150-45-1
1,3-bis(2-carboethoxychromon-5-yloxy)-2-hydroxypropane

Conditions

Conditions	Yield
In N,N-dimethyl-formamide 1.) 64-70 deg C, 5 h, 2.) 4-6 deg C, overnight;	136 g

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Chemistry

IUPAC Name: Disodium 5-[3-(2-carboxylato-4-oxochromen-5-yl)oxy-2-hydroxypropoxy]-4-oxochromene-2-carboxylate
Product Categories: Drug bulk;Intermediates & Fine Chemicals;Pharmaceuticals
Molecular Formula: C₂₃H₁₄O₁₁·2 Na
Molecular Weight: 512.35
EINECS: 239-926-7
Melting Point: 241-2420 °C
Boiling Point: 752.3 °C at 760 mmHg
Flash Point: 263.9 °C
Enthalpy of Vaporization: 115.04 kJ/mol
Vapour Pressure: 8.92E-24 mmHg at 25°C
Appearance: White Crystalline Powder
Cromoglycate disodium's (15826-37-6) Synonyms: DSCG ; DISODIUM CROMOGLYCATE ; Disodium 5,5'-[(2-hydroxytrimethylene)dioxy]bis[4-oxo-4h-1-benzopyran-2-carboxylate] ; Disodium 1,3-bis(2-carboxy-5-chromonyloxy)-2-propanol ; CROMOGLYCATE SODIUM SALT ; CROMOGLYCIC ACID SODIUM SALT ; CROMOLYN SODIUM ; CROMOLYN SODIUM SALT
Cromoglycate disodium's (15826-37-6) Molecular Structure:

Uses

Chromone complex which blocks mast cell degranulation.

Toxicity Data With Reference

1.	orl-wmn TDLo:96 mg/kg/6D-I:SKN	BMJOAE British Medical Journal. 289 (1984),470.
2.	orl-hmn TDLo:34 mg/kg/4W:PUL	BMJOAE British Medical Journal. 2 (1976),916.
3.	scu-rat LD50:6 g/kg	NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),244.
4.	ipr-mus LD50:4100 mg/kg	NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),244.
5.	scu-mus LD50:4400 mg/kg	NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),244.
6.	ivn-mus LD50:3300 mg/kg	NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),244.
7.	ivn-rbt LD50:2 g/kg	KSRNAM Kiso to Rinsho. Clinical Report. 4 (1970),189.

Safety Profile

Moderately toxic by intravenous route. Mildly toxic by subcutaneous and intraperitoneal routes. Human systemic effects by ingestion: allergic dermatitis, respiratory depression and other lung effects. When heated to decomposition it emits toxic fumes of Na₂O.

Safety Information of Cromoglycate disodium(15826-37-6)
Hazard Codes: Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
RIDADR: 3249
WGK Germany: 2
RTECS: DJ2380000
HazardClass: 6.1(b)
PackingGroup: III