Chemoselective Aerobic Cross-Dehydrogenative Coupling of Terminal Alkynes with Hydrosilanes by a Nanoporous Gold Catalyst
Aerobic cross-dehydrogenative coupling between terminal alkynes and hydrosilanes occurred in the presence of nanoporous gold catalyst under O2 atmosphere. A variety of alkynylsilanes were synthesized in good-to-high yields and the catalyst was easily recovered and reused many times. Furthermore, the chemoselective direct silyl protection of terminal acetylenes of alkynols over the hydroxyl groups was achieved with this catalytic system.
Synthesis and evaluation of lipophilic Aza-C-glycosides as inhibitors of glucosylceramide metabolism
The structure-activity relationship of lipophilic aza-C-glycosides as inhibitors of the three enzymes of glucosylceramide metabolism is investigated. A library of β-aza-C-glycosides was synthesized with variations in N-alkylation and the linker length/typ
Wennekes, Tom,Van Den Berg, Richard J. B. H. N.,Boltje, Thomas J.,Donker-Koopman, Wilma E.,Kuijper, Bastiaan,Van Der Marel, Gijsbert A.,Strijland, Anneke,Verhagen, Carlo P.,Aerts, Johannes M. F. G.,Overkleeft, Herman S.
experimental part
p. 1258 - 1283
(2010/05/19)
Spirocyclic Azaindole Derivatives
The invention relates to substituted azaindole derivatives, to methods for the production thereof, to medicaments containing said compounds and to the use of substituted azaindole derivatives for producing medicaments.
-
Page/Page column 17
(2009/07/03)
On the Selective Deprotection of Trityl Ethers
-
Jones, Graham B.,Hynd, George,Wright, Justin M.,Sharma, Anu
p. 263 - 265
(2007/10/03)
Synthesis of the 5-HT1D receptor agonist MK-0462 via a Pd-catalyzed coupling reaction
Application of a palladium-catalyzed coupling between 3 and 5a to the synthesis of the novel 5-HT1D receptor agonist MK-0462 (1), a potential anti-migraine drug, is described.
Chen, Cheng-Yi,Lieberman, David R.,Larsen, Robert D.,Reamer, Robert A.,Verhoeven, Thomas R.,Reider, Paul J.,Cottrell, Ian F.,Houghton, Peter G.
p. 6981 - 6984
(2007/10/02)
More Articles about upstream products of 160194-29-6