160194-29-6

Basic information

• Product Name: 4-(TRIETHYLSILYL)-3-BUTYN-1-OL
• Synonyms: TIMTEC-BB SBB009039;4-(TRIETHYLSILYL)-3-BUTYN-1-OL;4-(triethylsilyl)but-3-yn-1-ol
• CAS NO: 160194-29-6
• Molecular Formula: C₁₀H₂₀OSi
• Molecular Weight: 184.35
• Mol File: 160194-29-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 224.2±23.0℃ (760 Torr)
• Flash Point: >63°C
• Appearance: /
• Density: 0.877±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.0187mmHg at 25°C
• Refractive Index: 1.4686
• Storage Temp.: 2-8°C
• PKA: 14.46±0.10(Predicted)
• CAS DataBase Reference: 4-(TRIETHYLSILYL)-3-BUTYN-1-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(TRIETHYLSILYL)-3-BUTYN-1-OL(160194-29-6)
• EPA Substance Registry System: 4-(TRIETHYLSILYL)-3-BUTYN-1-OL(160194-29-6)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 160194-29-6(Hazardous Substances Data)

Usage

General Description

4-(Triethylsilyl)-3-butyn-1-ol is a chemical compound with the molecular formula C11H24OSi. It is an organosilicon compound that contains a triethylsilyl group attached to a butyn-1-ol group. It is commonly used as a reagent in organic synthesis, particularly in the production of various organic compounds. 4-(TRIETHYLSILYL)-3-BUTYN-1-OL is often employed in the preparation of pharmaceuticals, agrochemicals, and other fine chemicals. Its unique structure and properties make it a versatile building block for the synthesis of complex organic molecules. Additionally, it can be used as a protecting group for alcohols and as a precursor in various chemical reactions.

InChI:InChI=1/C10H20OSi/c1-4-12(5-2,6-3)10-8-7-9-11/h11H,4-7,9H2,1-3H3

Upstream product

• 617-86-7 triethylsilane 
• 927-74-2 3-Butyn-1-ol 
• 994-30-9 triethylsilyl chloride 
• 160194-28-5 1-triethylsilanyl-4-(triethylsilanyloxy)but-1-yne 

Downstream Products

• 1258504-28-7 N-(2-(5-chloro-7-fluoro-2-(triethylsilyl)-1H-indol-3-yl)ethyl)-5-(2,5-difluorobenzyl)isoxazole-3-carboxamide 
• 1258504-39-0 N-(2-(5-chloro-2-(triethylsilyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)ethyl)-5-(2,5-difluorobenzyl)isoxazole-3-carboxamide 
• 1382991-58-3 N-(2-(5-chloro-7-fluoro-2-(triethylsilyl)-1H-indol-3-yl)ethyl)-4-(3-fluorobenzyl)benzamide 
• 1382991-57-2 4-(3-fluorobenzyl)-N-(2-(4,5,6-trifluoro-2-(triethylsilyl)-1H-indol-3-yl)ethyl)benzamide 
• 1382991-56-1 N-(2-(5-acetyl-2-(triethylsilyl)-1H-indol-3-yl)ethyl)-4-(3-fluorobenzyl)benzamide 
• 1382991-55-0 N-(2-(5-cyano-2-(triethylsilyl)-1H-indol-3-yl)ethyl)-4-(3-fluorobenzyl)benzamide 
• 1382991-52-7 4-(3-fluorobenzyl)-N-(4-(triethylsilyl)but-3-ynyl)benzamide 
• 320782-27-2 4-(triethylsilanyl)but-3-ynyl-4-methylbenzenesulfonate 
• 864550-46-9 6-benzyloxy-3-(2-hydroxy-ethyl)-7-methyl-2-triethylsilanyl-1H-indole-4-carbonitrile 

Relevant articles and documents

Chemoselective Aerobic Cross-Dehydrogenative Coupling of Terminal Alkynes with Hydrosilanes by a Nanoporous Gold Catalyst

Aerobic cross-dehydrogenative coupling between terminal alkynes and hydrosilanes occurred in the presence of nanoporous gold catalyst under O2 atmosphere. A variety of alkynylsilanes were synthesized in good-to-high yields and the catalyst was easily recovered and reused many times. Furthermore, the chemoselective direct silyl protection of terminal acetylenes of alkynols over the hydroxyl groups was achieved with this catalytic system.

Spirocyclic Azaindole Derivatives

The invention relates to substituted azaindole derivatives, to methods for the production thereof, to medicaments containing said compounds and to the use of substituted azaindole derivatives for producing medicaments.

Synthesis of the 5-HT1D receptor agonist MK-0462 via a Pd-catalyzed coupling reaction

Application of a palladium-catalyzed coupling between 3 and 5a to the synthesis of the novel 5-HT1D receptor agonist MK-0462 (1), a potential anti-migraine drug, is described.