- Benzylamine derivatives and its application on the medicament
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The invention provides novel benzylamine derivatives or stereoisomers, geometric isomers, tautomers, nitric oxides, hydrates, solvates, metabolites and pharmaceutically acceptable salt or prodrugs of the benzylamine derivatives, which are used for treatin
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Paragraph 0627; 0629-0632; 0693-0698
(2019/02/26)
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- Efficient cyclopropanation of aryl/heteroaryl acetates and acetonitriles with vinyl diphenyl sulfonium triflate
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A convenient method was developed for the cyclopropanation of aryl acetates and aryl acetonitrile using vinyl diphenyl sulfonium triflate salt. The newly developed conditions are simple, mild, and compatible with a wide range of functional groups, without the need to apply an inert atmosphere, or alkali bases.
- Zhou, Mingwei,Hu, Yimin,En, Ke,Tan, Xuefei,Shen, Hong C.,Qian, Xuhong
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supporting information
p. 1443 - 1445
(2018/03/12)
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- Enantioselective C-H Functionalization-Addition Sequence Delivers Densely Substituted 3-Azabicyclo[3.1.0]hexanes
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An enantioselective C-H functionalization route to perfluoroalkyl-containing 3-azabicyclo[3.1.0]hexanes is disclosed. A modular and bench-stable diazaphospholane ligand enables highly enantioselective Pd(0)-catalyzed cyclopropane C-H functionalization using trifluoroacetimidoyl chlorides as electrophilic partners. In turn, the resulting cyclic ketimine products react smoothly with a broad variety of nucleophiles in one-pot processes enabling the rapid and modular construction of heavily substituted pyrrolidines.
- Pedroni, Julia,Cramer, Nicolai
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supporting information
p. 12398 - 12401
(2017/09/25)
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- Naphthalene derivatives and their application on the medicament
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The invention provides a number of naphthalene derivatives or stereoisomers, tautomers, nitrogen oxides, metabolites, pharmaceutically acceptable salts or prodrugs thereof which are used for excitement of melatonin receptors. The invention also discloses pharmaceutical compositions containing such compounds and application thereof in treatment of central nervous system dysfunction of mammals, especially human.
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Paragraph 0221; 0222; 0234; 0236; 0237
(2018/10/04)
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- SULFONAMIDE DERIVATIVES AND PHARMACEUTICAL APPLICATIONS THEREOF
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Provided herein are sulfonamide derivatives or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, and their uses for treating Alzheimer's disease. Also provided herein are pharmaceutical compositions containing such compounds, and use of such compounds or pharmaceutical compositions thereof for managing or treating 5-HT6 receptor-mediated diseases, especially in the manufacture of a medicament for managing or treating Alzheimer's disease.
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Paragraph 00249; 00259
(2015/11/09)
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