1647055-46-6Relevant articles and documents
Benzylamine derivatives and its application on the medicament
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Paragraph 0627; 0629-0632; 0693-0698, (2019/02/26)
The invention provides novel benzylamine derivatives or stereoisomers, geometric isomers, tautomers, nitric oxides, hydrates, solvates, metabolites and pharmaceutically acceptable salt or prodrugs of the benzylamine derivatives, which are used for treatin
Enantioselective C-H Functionalization-Addition Sequence Delivers Densely Substituted 3-Azabicyclo[3.1.0]hexanes
Pedroni, Julia,Cramer, Nicolai
supporting information, p. 12398 - 12401 (2017/09/25)
An enantioselective C-H functionalization route to perfluoroalkyl-containing 3-azabicyclo[3.1.0]hexanes is disclosed. A modular and bench-stable diazaphospholane ligand enables highly enantioselective Pd(0)-catalyzed cyclopropane C-H functionalization using trifluoroacetimidoyl chlorides as electrophilic partners. In turn, the resulting cyclic ketimine products react smoothly with a broad variety of nucleophiles in one-pot processes enabling the rapid and modular construction of heavily substituted pyrrolidines.
SULFONAMIDE DERIVATIVES AND PHARMACEUTICAL APPLICATIONS THEREOF
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Paragraph 00249; 00259, (2015/11/09)
Provided herein are sulfonamide derivatives or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, and their uses for treating Alzheimer's disease. Also provided herein are pharmaceutical compositions containing such compounds, and use of such compounds or pharmaceutical compositions thereof for managing or treating 5-HT6 receptor-mediated diseases, especially in the manufacture of a medicament for managing or treating Alzheimer's disease.
