138113-08-3Relevant articles and documents
An efficient synthesis of 7-methoxy-1-naphthylacetic acid
Chinea, Kimberly,Vera, William J.,Sanchez, Jennifer,Banerjee, Ajoy K.
, p. 328 - 331 (2013)
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Preparation method of agomelatine intermediate
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Paragraph 0038-0062, (2021/03/31)
The invention relates to a preparation method of an agomelatine intermediate. Specifically, the invention provides a preparation method of an agomelatine important intermediate 2-(7-methoxy-1-naphthyl)acetonitrile II, 7-methoxy-1-tetralone is used as an initial raw material, condensation and oxidation reactions are carried out to obtain the intermediate 2-(7-methoxy-1-naphthyl)acetonitrile, and the preparation method has the advantages of good yield, high product purity, simple reaction and easy operation, and is suitable for industrial production .
A compound and its preparation method and application
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Paragraph 0142; 0143; 0144; 0145, (2017/06/14)
The invention provides a 1-cyan-1-(7-methoxyl-3, 4-dihdyro-1-naphthyl) methanol ester compound shown as a structural formula I described in the specification, wherein R is H, C1-C6 aliphatic groups or aryl. The invention further provides a preparation method of the compound and an application thereof in preparing agomelatine. The method of synthesizing agomelatine by the 1-cyan-1-(7-methoxyl-3, 4-dihdyro-1-naphthyl) methanol ester compound shown as the structural formula I is mild in condition, lower in production cost, higher in yield and fewer in impurities in end-products of reaction, and is more suitable for industrialized production.