6836-21-1Relevant articles and documents
A Practical synthesis of (7-methoxynaphth-l-yl)acetic acid
Tang, Jia-Deng,Cen, Jun-Da
, p. 164 - 168 (2009)
-
Modular Synthesis of Arylacetic Acid Esters, Thioesters, and Amides from Aryl Ethers via Rh(II)-Catalyzed Diazo Arylation
Best, Daniel,Jean, Micka?l,Van De Weghe, Pierre
, p. 7760 - 7770 (2016/09/12)
One-pot formation of arylacetic acid esters, thioesters, and amides via Rh(II)-catalyzed arylation of a Meldrum's acid-derived diazo reagent with electron-rich arenes is described. The methodology was used to efficiently synthesize an anticancer compound.
AGOMELATINE AND PHARMACEUTICAL COMPOSITIONS THEREOF
-
Page/Page column 7, (2012/07/27)
Agomelatine crystal, which is a drug for treating depression, and pharmaceutical compositions thereof are provided. The X-ray powder diffraction spectra of such agomelatine crystal, which is irradiated by Cu-Kα and showed by 20(degree), has characteristic diffraction peaks at 12.84, 13.84, 16.14, 18.56, 19.12, 20.86, 21.20, 23.84; its IR absorption pattern has characteristic absorption peaks at about 3234, 3060, 2940, 1638, 1511, 1436, 1249, 1215, 1184, 1032, 908, 828, 755, 588 cm-1; and its DSC endothermic transition temperature is 97.6°C. The use of the agomelatine crystal as an active ingredient in preparing a medicament for the treatment of depression is also provided.