- A microporous lanthanide-tricarboxylate framework with the potential for purification of natural gas
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A novel robust three-dimensional lanthanide organic framework with high thermal stability has been demonstrated to exhibit the potential for purification of natural gas in nearly pure form from an 8-component gas mixture at room temperature.
- He, Yabing,Xiong, Shunshun,Chen, Banglin,Xiang, Shengchang,Zhang, Zhangjing,Fronczek, Frank R.,Krishna, Rajamani,O'Keeffe, Michael
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p. 10856 - 10858,3
(2012)
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- Europium amphiphilic naphthalene based complex for the enhancement of linearly polarized luminescence in Langmuir-Blodgett films
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Linearly polarized luminescence (LPL) in films of europium ions was induced by using naphthoic acid adopted alkyl chain (NaphC15), which plays the roles of both surfactant and photo-antenna. The synthesis of NaphC15 was newly developed, and the Eu complex composed in a 1:3 ratio of Eu3+ ion and NaphC15 was synthesized in the powder form for comparison. The structural aspects of LB films with a layered scheme were obtained from the measurements of synchrotron XRPD, X-ray photoelectron spectroscopy and waveguide polarized absorption spectra. Luminescence of europium in the film is more intense than that in the powdered complex. The luminescence efficiency calculated from the observed luminescence lifetimes and quantum yields also supported their structure-enhanced luminescence. Finally, we revealed that the LPL was sensitized by the electronic dipole moment localized on the NaphC15 moieties aligned independently in the Langmuir-Blodgett films.
- Yoshihara, Koushi,Yamanaka, Masamichi,Kanno, Shuhei,Mizushima, Soichi,Tsuchiyagaito, Junko,Kondo, Kazuki,Kondo, Takahiro,Iwasawa, Daichi,Komiya, Hiroaki,Saso, Akira,Kawaguchi, Shogo,Goto, Kenta,Ogata, Shuhei,Takahashi, Hiromi,Ishii, Ayumi,Hasegawa, Miki
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Read Online
- Oxime ether derivative and preparation method and application thereof
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The invention discloses oxime ether derivative and a preparation method and application thereof. The oxime ether derivative is shown as any one of 1) to 6), wherein the 1) is 5-bromine-1-naphthalene formaldehyde oxime ether, the 2) is 5-methoxy-1-naphthalene formaldehyde oxime ether, the 3) is 5-phenyl-1-naphthalene formaldehyde oxime ether, the 4) is 5-p-methoxyphenyl-1-naphthalene formaldehyde oxime ether, the 5) is 5-p-ethoxyphenyl-1-naphthalene formaldehyde oxime ether, and the 6) is 3-5-ethyl(E)-1-naphthalene formaldehyde oxime ether. According to the oxime ether derivative, 1-naphthoic acid is utilized as a raw material; the oxime ether derivative is synthesized by coupling reaction of Suzuki reaction, Heck reaction and the like, acylation reaction and oximation reaction. The compound disclosed by the invention has good antineoplastic activity and has a very good prospect in medicinal development.
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Paragraph 0068; 0069; 0075; 0077; 0084; 0085; 0092; 0093
(2018/08/03)
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- Total synthesis of danshenspiroketallactone
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Described herein is the first synthesis of the monobenz-annulated 5,5-spiroketals danshenspiroketallactone and epi-danshen-spiroketallactone, two components of the traditional Chinese medicine Danshen. Key features of the synthesis include a directed metallation-lactonisation sequence to install the isobenzofuranone moiety and an oxidative radical cyclisation to afford the monobenz-annulated 5,5-spiroketal. Georg Thieme Verlag Stuttgart. New York.
- Chorley, Daniel F.,Chen, Jack Li-Yang,Furkert, Daniel P.,Sperry, Jonathan,Brimble, Margaret A.
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scheme or table
p. 128 - 130
(2012/02/03)
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- Synthesis of monofluorinated 1-(naphthalen-1-yl)piperazines
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A series of regioisomerically monofluorinated 1-(naphthalen-1-yl)piperazines is described.
- Repine, Joseph T.,Johnson, Douglas S.,White, Andrew D.,Favor, David A.,Stier, Michael A.,Yip, Judy,Rankin, Trent,Ding, Qizhu,Maiti, Samarendra N.
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p. 5539 - 5541
(2008/02/13)
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- The mercury-mediated decarboxylation (Pesci reaction) of naphthoic anhydrides investigated by microwave synthesis
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The mercury-mediated decarboxylation (Pesci reaction) of several substituted naphthoic anhydrides has been investigated by microwave synthesis. A laboratory microwave reactor was found to be ideal for small-scale preparations of this slow reaction, reducing reaction times from typically four days to less than 1 h for the three-step process. The ionic reaction medium rapidly heated to high temperatures under microwave heating and could be efficiently maintained by low microwave power settings. Generation of stoichiometric CO2 was safely contained within the reaction tubes. A simplified reaction procedure has been developed. For substituted naphthoic anhydrides, 1H NMR analysis of the naphthoate ester derivatives indicated no change in the regioisomer ratio compared to previously reported thermal values.
- Moseley, Jonathan D.,Gilday, John P.
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p. 4690 - 4697
(2007/10/03)
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- Synthesis, antitumor and DNA photocleaving activities of novel naphthalene carboxamides: Effects of different thio-heterocyclic rings and aminoalkyl side chains
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Two kinds of thio-heterocyclic fused naphthalene carboxamides, 3a-b, 4a-b, were designed, synthesized and quantitatively evaluated as efficient antitumor and DNA photocleaving agents. Compound 3a or 3b, having the thiophene ring, intercalated into DNA mor
- Li, Zhigang,Yang, Qing,Qian, Xuhong
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p. 8711 - 8717
(2007/10/03)
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- Synthesis of mono- and difluoronaphthoic acids
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Aryl carboxamides are useful structural units found in several biologically active compounds. Unlike their benzoic acid counterparts, fluorinated versions of naphthoic acids are relatively unknown. In connection with a recent project, we needed viable syntheses of several mono- and difluorinated naphthoic acids. Herein we describe the synthesis of 5-, 6-, 7-, and 8-fluoro-1-naphthalenecarboxylic acids and 5,7-, 5,8-, 6,7-, and 4,5-difluoro-1-naphthalenecarboxylic acids. The 5-fluoro derivative 1 was obtained from the corresponding 5-bromo compound via electrophilic fluorination of the lithio-intermediate. The rest of the monofluoro (2, 3, and 4) and the difluoro acids (5, 6, and 7) were prepared by a new, general route which entailed the elaboration of commercial fluorinated phenylacetic acids to 2-(fluoroaryl)glutaric acids with differential ester groups; selective hydrolysis to a mono acid, intramolecular Friedel-Crafts cyclization, and aromatization furnished the target structures. An alternative process to assemble a naphthalene skeleton is also presented for the difluoro acids 5 and 6. Finally, 4,5-difluoro-1-naphthalenecarboxylic acid (8) was prepared expeditiously from 1,8-diaminonaphthalene by adapting classical reactions.
- Tagat, Jayaram R.,McCombie, Stuart W.,Nazareno, Dennis V.,Boyle, Craig D.,Kozlowski, Joseph A.,Chackalamannil, Samuel,Josien, Hubert,Wang, Yuguang,Zhou, Guowei
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p. 1171 - 1177
(2007/10/03)
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- Discovery of novel, orally active dual NK1/NK2 antagonists
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Exploration of the SAR around selective NK2 antagonists, SR48968 and ZD7944, led to the discovery that naphth-1-amide analogues provide potent dual NK1 and NK2 antagonists. ZD6021 inhibited binding of [3H]-NKA or [3H]-SP to human NK1 and NK2 receptors, with high-affinity (Ki=0.12 and 0.62 nM, respectively). In functional assays ZD6021 had, at 10-7 M, in human pulmonary artery pKB=8.9 and in human bronchus pKB=7.3, for NK1 and NK2, respectively. Oral administration of ZD6021 to guinea pigs dose-dependently attenuated ASMSP induced extravasation of plasma proteins, ED50=0.5 mg/kg, and NK2 mediated bronchoconstriction, ED50=13 mg/kg.
- Bernstein, Peter R.,Aharony, David,Albert, Jeffrey S.,Andisik, Donald,Barthlow, Herbert G.,Bialecki, Russell,Davenport, Timothy,Dedinas, Robert F.,Dembofsky, Bruce T.,Koether, Gerard,Kosmider, Benedict J.,Kirkland, Karin,Ohnmacht, Cyrus J.,Potts, William,Rumsey, William L.,Shen, Lihong,Shenvi, Ashok,Sherwood, Scott,Stollman, David,Russell, Keith
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p. 2769 - 2773
(2007/10/03)
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- Dihydropyrimidine derivatives
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Novel A-II receptor antagonists have the formula STR1 or its isomer STR2 wherein R1, R2, R3, R4, R5, and R6, are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensive agents.
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- SYNTHESIS AND POLYMERIZATION OF SOME ETHYNYL TRIFLUOROMETHYL NAPHTHALENES
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Some bromonaphthoic acids were fluorinated with SF4 to bromo(trifluoromethyl)naphthalenes.Although a reaction of Grignard reagent of one of the bromides with Cl2C=CF2 gave low yield of a (dichlorofluorovinyl)(trifluoromethyl)naphthalene, lithio derivatives gave the desired ethynyl(trifluoromethyl)naphthalenes in improved yields after subsequent eliminations of the vinylic halogens with n-butyllithium.Polymerization of the acetylenes was carried out with photo-activated W(CO)6 catalyst to yield high-molecular-weight polymers.
- Okano, T.,Ito, K.,Kodaira, K.,Hosokawa, K.,Nishida, M.,et al.
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p. 139 - 152
(2007/10/02)
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