- A Practical Synthesis of the Platelet Fibrinogen Antagonist, Elarofiban
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Elarofiban is a novel, nonpeptide, orally active fibrinogen receptor antagonist useful for the treatment of platelet mediated thrombotic disorders (Costanzo, M. J.; Hoekstra, W. J.; Maryanoff, B. E. WO, 97/41102,1997). Herein we describe the process research that was carried out for the synthesis of elarofiban that eventually led to the development of a safe and cost-effective commercial scale process.
- Cohen, Judith H.,Roessler, Armin,Scott, Lorraine,Sorgi, Kirk L.,Villani Jr., Frank J.,Webster, Robin R. H.,Weh, Christian,Bos, Mary Ellen,Cesco-Cancian, Sergio,Harris, Bruce D.,Hortenstine, John T.,Justus, Michael,Maryanoff, Cynthia A.,Mills, John,Muller, Stefan
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- Process for preparing [S- (R*, S*) ] -beta- [ [ [1- [1-oxo-3- (4-piperidinyl) propyl] -3-piperidinyl] carbonyl]amino] -3-pyridinepropanoic acid and derivatives
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A process for preparing a compound of formula I wherein R1 and R2 are independently selected from the group consisting of hydrogen, lower alkyl and halogen
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