- SUBSTITUTED AMINOPURINE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH
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Provided herein are Aminopurine Compounds having the following structures: wherein R1, R2, and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound, and methods for treating or preventing a cancer, for example, melanoma.
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- CHEMOKING RECEPTOR ANTAGONISTS
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Disclosed herein are chemokine receptor antagonists of formula (I) wherein G1, X1, X2, and X3 are as defined in the specification. Compositions comprising such compounds; and methods for treating conditions and disorders using such compounds and compositions are also described.
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- Efficient preparation of 4-methoxy-5,6-dihydro-2H-pyran
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We report the efficient synthesis of 4-methoxy-5,6-dihydro-2H-pyran (MDHP) via the TiCl4 driven elimination of MeOH from 4,4-dimethoxytetrahydropyran. The previous difficulty of preparing MDHP restricted the wider use of 4-methoxytetrahydropyran-4-yl (MTHP) acyclic acetals, which have desirable protecting group properties when compared to more commonly used MOM- and THP-acetals. The behaviour of the elimination on related acetals is also examined.
- Panchal, Nitesh,Fernandez-Yarza, Arantxa,Free, Paul,Gaffney, Piers R.J.
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p. 1836 - 1838
(2008/09/18)
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- Process for synthetizing polyoxyalkyleneglycol-mono-ethers
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Polyoxyalkylene-glycol-monoethers containing a desired number of oxyalkylene units are prepared by starting from a linear or branched aliphatic alcohol, preferably a primary linear aliphatic alcohol, or from a mono-hydroxy phenol, preferably bearing alkyl--substituents on its ring, and mono-halogenated linear oxyalkylene glycols, wherein the halogen is in a terminal position and the hydroxy group is protected by known means, under basic conditions, with polyoxyalkyleneglycol-monoethers being obtained, which contain a protected hydroxy group, from which the protecting group is removed by means of a treatment under acidic conditions, thus the desired product being obtained, which is useful as a non-ionic surfactant, in particular in the cosmetic and/or pharmaceutical field.
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