- Preparation method of nitrogen-containing heterocyclic derivative
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The invention discloses a preparation method of a nitrogen-containing heterocyclic derivative (4-(4-bromobenyl) piperazine-1-yl) piperidine-1-tert butyl formate. The preparation method comprises the following steps: taking 4-hydroxypyrazole as a starting raw material; and carrying out Boc feeding, condensation, nucleophilic substitution and amidation to obtain an objective product. The compound isan important medical intermediate.
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- Preparation method of piperazine derivative
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The invention discloses a preparation method of a piperazine derivative, namely (4-(4-trifluoromethyl benzoyl)piperazine-1-yl)piperidine-1-tert-butyl formate. 4-hydroxy piperazine is taken as a starting material and is subjected to Boc treatment, condensation, nucleophilic substitution and amidation to obtain a target product. The compound is an important medical intermediate.
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- Compound used as ALK (anaplastic lymphoma kinase) inhibitor and application thereof
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The invention discloses a compound shown in a formula I, and pharmaceutically acceptable salts, stereoisomers, solvates or predrugs. The symptoms are defined in claim requirements. The compound shownin the formula I has good inhibiting activity on ALK (anaplastic lymphoma kinase), and can be used for preparing medicines for adjusting the activity of the ALK activity or treating the ALK-related diseases, especially nonsmall-cell lung cancer drugs. (The formula I is shown in the attached figure.).
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- Preparation method for piperazine derivative
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The invention discloses a preparation method for a piperazine derivative (4-(4-methyl benzoyl) piperazine-1-yl) piperidine-1-tert-butyl formate. 4-hydroxy piperazine is taken as an initial raw material and then is subjected to Boc, condensation, nucleophilic substitution and amidation so as to acquire a target product. The compound is an important medical intermediate.
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- Puerarin derivative and its preparation method (by machine translation)
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The invention belongs to the technical field of organic synthetic chemistry, and provides a plurality of puerarin derivatives and preparation methods thereof. The prepared puerarin derivatives have good water solubility or fat solubility, and can be quick
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- PIPERAZINE-PIPERIDINE COMPOUNDS AS HEPATITIS C VIRUS INHIBITORS
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The invention provides compounds of formula (I): wherein the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are inhibitors of replication of the hepatitis C virus. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat hepatitis C viral infections, and processes and intermediates useful for preparing such compounds.
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- 5-Quinoline derivatives having an anti-bacterial activity
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The present invention describes novel anti-bacterial compounds of the formula (I). These compounds are, amongst others, of interest as inhibitors of DNA gyrase and topoisomerases, for example of topoisomerase II and IV.
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Page/Page column 32
(2010/12/31)
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- SUBSTITUTED BENZIMIDAZOLONE DERIVATIVES, MEDICAMENTS COMPRISING THEM AND THEIR USE
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The present invention relates to novel benzimidazolone derivatives of the general formula (I) in which the substituents R1, R2, R3, A1, A2, and B are as defined in claim 1, medicaments comprising these, and the use thereof for the prophylaxis and/or treatment of vasopressin-dependent diseases.
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Page/Page column 93-94
(2008/06/13)
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- Benzenesulphonamide derivatives, method for production and use thereof for treatment of pain
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The present invention concerns novel benzenesulphonamide compounds, defined by formula I and the description, their method of preparation and their use in therapy.
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Page/Page column 26
(2008/06/13)
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- Compounds with platelet aggregation inhibitor activity
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A compound represented by the general formula (I) and a pharmaceutically acceptable salt and solvate thereof having an effect for inhibiting the aggregation of platelets is disclosed: STR1 wherein A, B and C represent independently CH2 or C=O;
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