177276-41-4

Basic information

• Product Name: 4-PIPERAZIN-1-YL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• Synonyms: TERT-BUTYL 4-PIPERAZINOTETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE;4-PIPERAZIN-1-YL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-BOC-4-PIPERAZIN-1-YL-PIPERIDINE;tert-Butyl 4-(piperazin-1-yl)piperidine-1-carboxylate, 1-(tert-Butoxycarbonyl)-4-(piperazin-1-yl)piperidine;2-Methylpropan-2-yl 4-(piperazin-1-yl)piperidine-1-carboxylate;4-(1-Piperazinyl)-1-piperidinecarboxylic acid tert-butyl ester;4-(Piperazin-1-yl)piperidine, N-BOC protected;1-Boc-4-(1-piperazinyl)piperidine
• CAS NO: 177276-41-4
• Molecular Formula: C₁₄H₂₇N₃O₂
• Molecular Weight: 269.38
• Product Categories: pharmacetical
• Mol File: 177276-41-4.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 370.9±37.0 °C(Predicted)
• Appearance: /
• Density: 1.069
• Storage Temp.: 2-8°C(protect from light)
• PKA: 9.17±0.10(Predicted)
• CAS DataBase Reference: 4-PIPERAZIN-1-YL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PIPERAZIN-1-YL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(177276-41-4)
• EPA Substance Registry System: 4-PIPERAZIN-1-YL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(177276-41-4)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 177276-41-4(Hazardous Substances Data)

Usage

General Description

4-PIPERAZIN-1-YL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER, also known as Tert-Butyl 4-((4-aminopiperidine-1-carbonyl)amino)piperazine-1-carboxylate, is a chemical compound that belongs to the class of piperidine carboxylic acid esters. It is often used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 4-PIPERAZIN-1-YL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER has a molecular formula of C17H30N4O3 and a molecular weight of 338.445 g/mol. Tert-Butyl 4-((4-aminopiperidine-1-carbonyl)amino)piperazine-1-carboxylate is a colorless liquid at room temperature and is soluble in organic solvents. It is important to handle this chemical with care and follow proper safety protocols due to its potential hazards.

Upstream product

• 177276-40-3 4-(1-tert-butoxycarbonylpiperidin-4-yl)piperazine-1-carboxylic acid benzyl ester 
• 177276-39-0 1-(1,1-dimethylethoxycarbonyl)-4-[4-(phenylmethyl)-1-piperazinyl]piperidine 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 110-85-0 piperazine 
• 141699-59-4 1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate 
• 5382-16-1 4-HYDROXYPIPERIDINE 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 1010446-28-2 tert-butyl 4-{4-[2-(6-chloro-2-oxo-2,3-dihydrobenzimidazol-1-yl)-2-phenyl-acetyl]piperazin-1-yl}piperidine-1-carboxylate 
• 180532-38-1 Ethyl trans-4-[[4-[1-(tert-butyloxycarbonyl)-piperidin-4-yl]-piperazin-1-yl]-carbonyl]-cyclohexanecarboxylate 
• 1248730-72-4 C₂₄H₃₄F₃N₃O₃ 
• 1392889-16-5 C₂₆H₃₅N₉S 
• 1464155-86-9 tert-butyl 4-(4-(4-(3-(4-cyanophenyl)imidazo[1,2-a]pyridin-6-yl)benzoyl)piperazin-1-yl)piperidine-1-carboxylate 
• 1477815-41-0 4-[4-(4-bromo-3-trifluoromethoxyphenylcarbamoyl)piperazin-1-yl]piperidine-1-carboxylic acid tert-butyl ester 
• 1477815-42-1 4-{4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-trifluoromethoxyphenylcarbamoyl]piperazin-1-yl}piperidine-1-carboxylic acid tert-butyl ester 
• 1477815-91-0 4-[1-(2,2-dimethylpropionyl)piperidin-4-yl]piperazine-1-carboxylic acid(4-bromo-3-trifluoromethoxyphenyl)amide 
• 1477815-93-2 4-(piperidin-4-yl)piperazine-1-carboxylic acid (4-bromo-3-trifluoromethoxyphenyl)amide 
• 1477815-94-3 4-[1-(3-hydroxy-2,2-dimethylpropionyl)piperidin-4-yl]piperazine-1-carboxylic acid(4-bromo-3-trifluoromethoxyphenyl)amide 
• 1477816-38-8 {(S)-1-[(2S,4S)-4-methoxy-2-(4-{4'-[(4-(piperidin-4-yl)piperazine-1-carbonyl)amino]-2'-trifluoromethoxybiphenyl-4-yl}-1H-imidazol-2-yl)pyrrolidine-1-carbonyl]-2-methylpropyl}carbamic acid methyl ester 
• 1477816-43-5 {(S)-2-methyl-1-[(2S,4S)-4-methyl-2-(7-{4-[(4-(piperidin-4-yl)piperazine-1-carbonyl)amino]-2-trifluoromethoxyphenyl}-3H-naphtho[1,2-d]imidazol-2-yl)pyrrolidine-1-carbonyl]propyl}carbamic acid methyl ester 

Relevant articles and documents

Compound used as ALK (anaplastic lymphoma kinase) inhibitor and application thereof

The invention discloses a compound shown in a formula I, and pharmaceutically acceptable salts, stereoisomers, solvates or predrugs. The symptoms are defined in claim requirements. The compound shownin the formula I has good inhibiting activity on ALK (anaplastic lymphoma kinase), and can be used for preparing medicines for adjusting the activity of the ALK activity or treating the ALK-related diseases, especially nonsmall-cell lung cancer drugs. (The formula I is shown in the attached figure.).

Preparation method of piperazine derivative

The invention discloses a preparation method of a piperazine derivative, namely (4-(4-trifluoromethyl benzoyl)piperazine-1-yl)piperidine-1-tert-butyl formate. 4-hydroxy piperazine is taken as a starting material and is subjected to Boc treatment, condensation, nucleophilic substitution and amidation to obtain a target product. The compound is an important medical intermediate.

Puerarin derivative and its preparation method (by machine translation)

The invention belongs to the technical field of organic synthetic chemistry, and provides a plurality of puerarin derivatives and preparation methods thereof. The prepared puerarin derivatives have good water solubility or fat solubility, and can be quick