cas 17890-82-3, 2-Amino-3-cyano-5-methylpyrazine

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17890-82-3

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Novel 1-(2-aminopyrazin-3-yl)methyl-2-thioureas as potent inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2)
Novel 1-(2-aminopyrazin-3-yl)methyl-2-thioureas are described as inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). These compounds demonstrate potent in vitro activity against the enzyme with IC50 values as low as 15 nM, and suppress expression of TNFα in THP-1 cells and in vivo in an acute inflammation model in mice. The synthesis, structure-activity relationship (SAR), and biological evaluation of these compounds are discussed.
Lin, Songnian,Lombardo, Matthew,Malkani, Sunita,Hale, Jeffrey J.,Mills, Sander G.,Chapman, Kevin,Thompson, James E.,Zhang, Wen Xiao,Wang, Ruixiu,Cubbon, Rose M.,O'Neill, Edward A.,Luell, Silvi,Carballo-Jane, Ester,Yang, Lihu
scheme or table
p. 3238 - 3242
(2010/05/02)

Studies on Pyrazines; Part 20. A Simple Synthesis of 5-Substituted 2-Amino-3-cyanopyrazines: Useful Intermediates for Pteridine Synthesis
A new and convenient synthesis of 5-substituted 2-amino-3-cyanopyrazines 3 involving cyanation of the corresponding 2-amino-3-bromopyrazines 2 with sodium dicyanocuprate is reported.
Sato, Nobuhiro,Takeuchi, Ryo
p. 659 - 660
(2007/10/02)

Pteridines. 47. Preparation and Chemistry of 2-Amino-6-carbalkoxy-3-cyano-5-substituted Pyrazine 1-Oxides: Synthesis of Pterin-6-carboxaldehyde
A new procedure for the synthesis of 2-amino-3-cyano-5-substituted pyrazines 9, useful intermediates for the synthesis of pteridines, is described.Oximation of β-keto esters 2 followed by reaction with aminomalononitrile provides 2-amino-6-carbalkoxy-3-cyano-5-substituted pyrazine 1-oxides 5.Protection of the amino group as its ((dimethylamino)methylene)amino derivative 9 followed by SN2 decarbalkoxylation provides pyrazines 10 which on removal of the protecting group and deoxygenation give pyrazines 8.This method is designed to be of use in cases where the β-keto ester cannot be converted directly to the corresponding α-keto aldoxime 3.The procedure is applied to the synthesis of 2-amino-3-cyano-5-(dimethoxymethyl)pyrazine (8a), an intermediate in the synthesis of pterin-6-carboxaldehyde (1).
Taylor, Edward C.,Dumas, Donald J.
p. 2485 - 2489
(2007/10/02)

Pyrazine diuretics. V. N-Amidino-3-aminopyrazinecarboxamidines and analogous 2,4-diaminopteridines.
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Jones,Cragoe Jr.
p. 322 - 325
(2007/10/08)

Chemical Properties

Appearance/Colour :White solid
Melting Point: 172 °C
Boiling Point: 348.9 °C at 760 mmHg
Flash Point:348.9 °C at 760 mmHg
Density: 1.27 g/cm³
Storage Temp.:2-8°C
PKA: 1.73±0.10(Predicted)
PSA: 75.59000
LogP: 0.82008

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17890-82-3

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Chemical Properties

Appearance/Colour :White solid

Melting Point: 172 °C

Boiling Point: 348.9 °C at 760 mmHg

Flash Point:348.9 °C at 760 mmHg

Density: 1.27 g/cm³

Storage Temp.:2-8°C

PKA: 1.73±0.10(Predicted)

PSA: 75.59000

LogP: 0.82008

Global suppliers and manufacturers of 17890-82-3total 11 suppliers on LookChem

Article Database

17890-82-3

Articles about 17890-82-3Total 4 be found

More Articles about upstream products of 17890-82-3

Chemical Properties

Appearance/Colour :White solid

Melting Point: 172 °C

Boiling Point: 348.9 °C at 760 mmHg

Flash Point:348.9 °C at 760 mmHg

Density: 1.27 g/cm3

Storage Temp.:2-8°C

PKA: 1.73±0.10(Predicted)

PSA: 75.59000

LogP: 0.82008

Global suppliers and manufacturers of 17890-82-3total 11 suppliers on LookChem

Density: 1.27 g/cm³