17890-82-3

Basic information

• Product Name: 2-Amino-3-cyano-5-methylpyrazine
• Synonyms: 2-Amino-3-cyano-5-methylpyrazine;3-Amino-6-methylpyrazine-2-carbonitrile
• CAS NO: 17890-82-3
• Molecular Formula: C6H6N4
• Molecular Weight: 134.13864
• Product Categories: Pyrazines, Pyrimidines & Pyridazines;Pyrazines, Pyrimidines & Pyridazines
• Mol File: 17890-82-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 167-171 °C
• Boiling Point: 348.9 °C at 760 mmHg
• Flash Point: 348.9 °C at 760 mmHg
• Appearance: White solid
• Density: 1.27 g/cm³
• Storage Temp.: 2-8°C
• PKA: 1.73±0.10(Predicted)
• CAS DataBase Reference: 2-Amino-3-cyano-5-methylpyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-3-cyano-5-methylpyrazine(17890-82-3)
• EPA Substance Registry System: 2-Amino-3-cyano-5-methylpyrazine(17890-82-3)

Safety Data

• Hazardous Substances Data: 17890-82-3(Hazardous Substances Data)

Usage

General Description

2-Amino-3-cyano-5-methylpyrazine is a chemical compound with the molecular formula C7H7N5. It is a pyrazine derivative that contains an amino group, a cyano group, and a methyl group. 2-Amino-3-cyano-5-methylpyrazine is commonly used as a flavoring agent in the food industry, adding a roasted and nutty flavor to various food products. It is also used in the production of pharmaceuticals and agrochemicals. Additionally, 2-Amino-3-cyano-5-methylpyrazine has been studied for its potential antioxidant and anti-inflammatory properties, making it a promising candidate for various medicinal applications. However, it is important to handle this chemical with care, as it may have harmful effects if not used properly.

Upstream product

• 820250-28-0 3-amino-6-methyl-pyrazine-2-carboxylic acid amide 
• 73198-27-3 2-Amino-6-(carbomethoxy)-3-cyano-5-methylpyrazine 1-oxide 
• 74290-65-6 2-amino-3-bromo-5-methylpyrazine 
• 73198-31-9 2-Amino-6-(carbomethoxy)-3-cyano-5-methylpyrazine 

Relevant articles and documents

Novel 1-(2-aminopyrazin-3-yl)methyl-2-thioureas as potent inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2)

Novel 1-(2-aminopyrazin-3-yl)methyl-2-thioureas are described as inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). These compounds demonstrate potent in vitro activity against the enzyme with IC50 values as low as 15 nM, and suppress expression of TNFα in THP-1 cells and in vivo in an acute inflammation model in mice. The synthesis, structure-activity relationship (SAR), and biological evaluation of these compounds are discussed.

Pteridines. 47. Preparation and Chemistry of 2-Amino-6-carbalkoxy-3-cyano-5-substituted Pyrazine 1-Oxides: Synthesis of Pterin-6-carboxaldehyde

A new procedure for the synthesis of 2-amino-3-cyano-5-substituted pyrazines 9, useful intermediates for the synthesis of pteridines, is described.Oximation of β-keto esters 2 followed by reaction with aminomalononitrile provides 2-amino-6-carbalkoxy-3-cyano-5-substituted pyrazine 1-oxides 5.Protection of the amino group as its ((dimethylamino)methylene)amino derivative 9 followed by SN2 decarbalkoxylation provides pyrazines 10 which on removal of the protecting group and deoxygenation give pyrazines 8.This method is designed to be of use in cases where the β-keto ester cannot be converted directly to the corresponding α-keto aldoxime 3.The procedure is applied to the synthesis of 2-amino-3-cyano-5-(dimethoxymethyl)pyrazine (8a), an intermediate in the synthesis of pterin-6-carboxaldehyde (1).