73198-31-9

Basic information

• Product Name: Pyrazinecarboxylic acid, 6-amino-5-cyano-3-methyl-, methyl ester (9CI)
• Synonyms: Pyrazinecarboxylic acid, 6-amino-5-cyano-3-methyl-, methyl ester (9CI)
• CAS NO: 73198-31-9
• Molecular Formula: C8H8N4O2
• Molecular Weight: 192.17472
• Product Categories: AMINOACID
• Mol File: 73198-31-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Pyrazinecarboxylic acid, 6-amino-5-cyano-3-methyl-, methyl ester (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrazinecarboxylic acid, 6-amino-5-cyano-3-methyl-, methyl ester (9CI)(73198-31-9)
• EPA Substance Registry System: Pyrazinecarboxylic acid, 6-amino-5-cyano-3-methyl-, methyl ester (9CI)(73198-31-9)

Safety Data

• Hazardous Substances Data: 73198-31-9(Hazardous Substances Data)

Upstream product

• 73708-95-9 methyl 3-oxo-2-oximinobutanoate 
• 73198-27-3 2-Amino-6-(carbomethoxy)-3-cyano-5-methylpyrazine 1-oxide 

Downstream Products

• 17890-82-3 3-amino-6-methylpyrazine-2-carbonitrile 

Relevant articles and documents

Pteridines. 47. Preparation and Chemistry of 2-Amino-6-carbalkoxy-3-cyano-5-substituted Pyrazine 1-Oxides: Synthesis of Pterin-6-carboxaldehyde

A new procedure for the synthesis of 2-amino-3-cyano-5-substituted pyrazines 9, useful intermediates for the synthesis of pteridines, is described.Oximation of β-keto esters 2 followed by reaction with aminomalononitrile provides 2-amino-6-carbalkoxy-3-cyano-5-substituted pyrazine 1-oxides 5.Protection of the amino group as its ((dimethylamino)methylene)amino derivative 9 followed by SN2 decarbalkoxylation provides pyrazines 10 which on removal of the protecting group and deoxygenation give pyrazines 8.This method is designed to be of use in cases where the β-keto ester cannot be converted directly to the corresponding α-keto aldoxime 3.The procedure is applied to the synthesis of 2-amino-3-cyano-5-(dimethoxymethyl)pyrazine (8a), an intermediate in the synthesis of pterin-6-carboxaldehyde (1).