- Synthesis of antioxidative and anti-inflammatory drugs glucoconjugates
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Glucoconjugates of (±)-ibuprofen, (±)-α-tocopherol (vitamin E), gentisic acid, gallic acid, 2,6-bis(tert-butyl)-4-thiophenol, and N-acetyl-L-cysteine were prepared with the objective of increasing the bioavailability of such antioxidant and anti-inflammatory drugs. The O-glucosides were synthesized using benzylated α-D-glucopyranosyl trichloracetimidate as glycosyl donor. For the synthesis of the S-glucosides, the glycosyl donor 1,2,3,4,6-penta-O-acetyl-β-D-glucopyranose provided higher yields than the corresponding O-acetylated imidate. Copyright (C) 2000 Elsevier Science Ltd.
- Uhrig, Rainer K.,Picard, Martin A.,Beyreuther, Konrad,Wiessler, Manfred
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- PHENOLIC GLUCOSIDE GALLATES FROM QUERCUS MONGOLICA AND Q. ACUTISSIMA
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Six phenolic glucoside gallates: D-threo-guaiacylglycerol 8-O-, L-threo-guaiacylglycerol 8-O-, 3-methoxy-4-hydroxyphenol 1-O-, gentisic acid 5-O, 3,5-dimethoxy-4-hydroxyphenol 1-O- and cis-coniferyl alcohol 4-O-β-D-(6'-O-galloyl)glucopyranosides were isolated from Quercus mongolica and Q. acutissima. - Key Word Index: Quercus mongolica; Q. acutissima; Fagaceae; phenolic glucoside gallates; D-threo-guaiacylglycerol; L-threo-guaiacylglycerol; 3-methoxy-4-hydroxyphenol; gentisic acid; 3,5-dimethoxy-4-hydroxyphenol; cis-coniferyl alcohol.
- Ishimaru, Kanji,Nonaka, Gen-Ichiro,Nishioka, Itsuo
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p. 1147 - 1152
(2007/10/02)
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