1820-89-9Relevant articles and documents
Synthesis of antioxidative and anti-inflammatory drugs glucoconjugates
Uhrig, Rainer K.,Picard, Martin A.,Beyreuther, Konrad,Wiessler, Manfred
, p. 72 - 80 (2007/10/03)
Glucoconjugates of (±)-ibuprofen, (±)-α-tocopherol (vitamin E), gentisic acid, gallic acid, 2,6-bis(tert-butyl)-4-thiophenol, and N-acetyl-L-cysteine were prepared with the objective of increasing the bioavailability of such antioxidant and anti-inflammatory drugs. The O-glucosides were synthesized using benzylated α-D-glucopyranosyl trichloracetimidate as glycosyl donor. For the synthesis of the S-glucosides, the glycosyl donor 1,2,3,4,6-penta-O-acetyl-β-D-glucopyranose provided higher yields than the corresponding O-acetylated imidate. Copyright (C) 2000 Elsevier Science Ltd.