- Enantiospecific synthesis of trisubstituted butyrolactone natural products and their analogs
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A general methodology for the synthesis of highly substituted butyrolactones in enantiomerically pure form has been developed. The application of this process in a highly efficient synthesis of lactone natural products blastmycinone (1), NFX-2 (2), antimycinone (3), and NFX-4 (4) and two lipid metabolites (5, 6) are described. Additionally, the total synthesis of 5-epi-blastmycinone (22), 5-epi-NFX-2 (21b), 5-epi-NFX-4 (21c), and lipid metabolite analogs (19, 20) are also described. The overall yields for the target molecules are the highest reported so far in the literature.
- Sibi, Mukund P.,Lu, Jianliang,Talbacka, Chelsy L.
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p. 7848 - 7855
(2007/10/03)
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