- A simple and efficient synthesis of [3α-3H]5α- androst-16-en-3β-ol
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An efficient one step synthesis of [3α-3H]5α- androst-16-en -3β-ol by NaBT4 reduction of a ketone precursor is described. The specific activity of the product was 21.6 Ci/mmol with a radiochemical purity >99%. Synthesis of the precursor, 5α-androst-16- en-3-one, from commercially available 5α-androst-16-en-3α-ol is also presented. Copyright
- Ren,Hesk,McNamara,Koharski
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- Synthesis of deuterium-labeled d3-androstenone and d 3-skatole for boar taint analysis
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The steroidal pig pheromone androstenone (5α-androst-16-en-3-one) as well as the indole derivate skatole are known to be the major compounds contributing to boar taint. The preparation of 2H-labeled internal standards of androstenone and skatole for stable isotope dilution assay-gas chromatography-mass spectrometry analysis of pig back fat samples is presented. The synthesis of d3-androstenone is highlighted by a palladium catalyzed deuteration of a Δ5,6-double bond of a hydrophobic steroid in a polar, D2O-containing solvent mixture. Moreover, the utilization of D2O as a deuterium source with in situ formation of D2 by means of Mg0 was found to be a very feasible and convenient alternative with respect to costs and technical effort.
- Fischer, Jochen,Elsinghorst, Paul W.,Wuest, Matthias
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p. 591 - 596
(2011/12/03)
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- Convenient synthesis of monomeric steroids from steroidal oxalate dimers using flash vacuum pyrolysis (FVP)
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Flash vacuum pyrolysis (FVP) or thermolysis (FVT), an environmentally friendly method for studying organic reaction mechanisms as well as synthesis, was applied to a series of oxalate dimers (1, 3, 5, 7, 9, 11, 13, and 15) to synthesise monomeric enes, dienes, and a triene (2, 4, 6, 8, 10, 12, 14, and 16). All steroidal monomers were identified by spectroscopic means. TUBITAK.
- Nahar, Lutfun,Turner, Alan B.,Sarker, Satyajit D.
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experimental part
p. 359 - 366
(2010/11/03)
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- Fragrance compositions and other compositions which contain human pheromones
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The invention concerns novel, non-therapeutic fragrance compositions and other compositions containing an odorant and a naturally occurring human pheromone. The invention also concerns fragrance compositions containing mixtures of naturally occurring human pheromones. The human pheromones disclosed are steroids which desirably belong to two distinct chemical classes: 16-Androstenes and Estrenes.
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