- Process method for preparing acetylthiocholine iodide
-
The invention discloses a process method for preparing acetylthiocholine iodide, which comprises the following steps: 1) reacting potassium thioacetate used as a raw material with 1,2-dichloroethane under the action of a catalyst to obtain 2-chloroethane thioacetate; 2) reacting the 2-chloroethane thioacetate as a raw material with iodized salt to obtain 2-iodoethane thioacetate; and 3) reacting the 2-iodoethane thioacetate as a raw material with a trimethylamine compound to obtain the acetylthiocholine iodide. The method is high in safety, mild in reaction condition and high in reaction yield.
- -
-
Paragraph 0042; 0048-0051; 0061; 0067-0070
(2020/07/12)
-
- Acetylthiocholine iodide as well as preparation method and application thereof
-
The invention provides acetylthiocholine iodide and a preparation method thereof. The preparation method comprises the following steps: step S1, dissolving a dimethylamino ethane compound in alkali toobtain an alkaline aqueous solution; step S2, adding a thioacetic acid compound into the alkaline aqueous solution to subject the thioacetic acid compound and the dimethylamino ethane compound to a thioreaction to generate (2-(dimethylamino)ethyl)ethanethioate; S3, separating the (2-(dimethylamino)ethyl)ethanethioate, and preparing an organic solution of the (2-(dimethylamino)ethyl)ethanethioate;and S4, dropwise adding an organic iodide into the organic solution of the (2-(dimethylamino)ethyl)ethanethioate for an iodination reaction so as to generate the acetylthiocholine iodide. According to the preparation method provided by the embodiment of the invention, the high-purity acetylthiocholine iodide can be obtained, and the titration content, the melting point, the clarity and other dataof the product are very excellent. The method is simple in operation, good in safety, suitable for industrial production, easy in raw material obtaining and low in cost.
- -
-
Paragraph 0065; 0068-0074; 0077-0083; 0086-0092; 0095-0101;
(2019/07/01)
-
