- ROMATIC COMPOUNDS AND PHARMACEUTICAL USES THEREOF
-
The present disclosure relates to compounds of the general formula (I): wherein R1, R2, R3, R4, R5, R6, and R7 may be chosen from different substituents; n is 0, 1, or 2; and X is a hydroxymethyl or a carboxylic acid or a derivative thereof, such as a carboxylate, such as a carboxylic ester, a glyceride, an anhydride, a phospholipid, a carboxamide, a phospholipid, or a prodrug thereof; or a pharmaceutically acceptable salt, solvate, solvate of such salt or a prodrug thereof. The present disclosure also relates to pharmaceutical compositions and lipid compositions comprising at least one compound according to the present disclosure, and to such compounds for use as medicaments or for use in therapy, in particular for the treatment of diseases related to metabolic diseases and liver diseases, such as non-alcoholic fatty liver disease and cholestasis diseases.
- -
-
-
- CRBN LIGANDS AND USES THEREOF
-
The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of CRBN, and the treatment of CRBN-mediated disorders.
- -
-
Paragraph 00455-00457
(2019/08/20)
-
- TROPANE COMPOUNDS
-
A compound according to Formula I or II: (I) or (II) wherein R1, R1b, R2, L1, and L2 and L2b are as defined in the specification, pharmaceutical compositions thereof, and methods of use thereof.
- -
-
Page/Page column 400
(2009/05/30)
-
- Novel structures derived from 2-[[(2-pyridyl)methyl]thio]-1H-benzimidazole as anti-Helicobacter pylori agents, Part 1
-
2-[[(2-Pyridyl)methyl]thio]-1H-benzimidazoles (2, sulfides) exhibit antibacterial properties that are selective for Helicobacter spp., but they also have an inherent susceptibility to metabolic oxidation to furnish 2-[[(2-pyridyl)methyl]sulfinyl]-1H-benzi
- Kühler, Thomas C.,Swanson, Marianne,Christenson, Beritte,Klintenberg, Ann-Charlotte,Lamm, Bo,F?gerhag, Jonas,Gatti, Roberto,?lweg?rd-Halvarsson, Maria,Shcherbuchin, Vladimir,Elebring, Thomas,Sj?str?m, Jan-Erik
-
p. 4282 - 4299
(2007/10/03)
-
- Pyrazol-4-ylbenzoyl derivatives and their use as herbicides
-
Pyrazol-4-ylbenzoyl derivatives where the substituents L, M, X, Y and n have the meanings given in claim1and Q is a pyrazole ring, linked in the 4-position, of the formula II where R15is C1-C4-alkyl, R16is hydro
- -
-
-
- Benzoyl derivatives
-
PCT No. PCT/EP96/03800 Sec. 371 Date Feb. 26, 1998 Sec. 102(e) Date Feb. 26, 1998 PCT Filed Aug. 29, 1996 PCT Pub. No. WO97/09324 PCT Pub. Date Mar. 13, 1997Benzoyl derivatives of the formula I where the substituents L, M, X, Y and n have the meaning give
- -
-
-