- Co-production process of methyl 3-hydroxy-2-methyl benzoate and methyl 3-methoxy-2-methyl benzoate
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The invention discloses a co-production process of 3-hydroxy-2-methyl benzoate and 3-methoxy-2-methyl benzoate, which comprises the following steps: (1) reduction hydrogenation reaction: by taking 2-methyl-3-nitrobenzoic acid or methyl 2-methyl-3-nitroben
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Paragraph 0014; 0026; 0030; 0034; 0037; 0040; 0044; 0048; ..
(2021/07/17)
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- Synthesis process 2 - methyl -3 - methoxybenzoic acid
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The invention discloses a synthesis process of 2 - methyl -3 - methoxybenzoic acid, which comprises the following steps: (1) reducing hydrogenation reaction: taking 2 - methyl -3 - nitrobenzoic acid or 2 - methyl -3 - nitrobenzoate as raw materials and methanol as a solvent. The hydrogen is a hydrogen source, and palladium carbon or platinum carbon is used as a catalyst to prepare 3 - amino -2 - methyl benzoic acid or 3 - amino -2 - methyl benzoic acid methyl ester by hydrogenation reduction. (2) Diazotization and hydrolysis and esterification one-pot reaction: preparing and hydroxyl 3 - methyl benzoic acid methyl ester by carrying out diazotization and hydrolysis -2 - esterification reaction under the action of a reducing product as a raw material and methanol as a solvent and a diazotization reagent. (3) Methylation reaction: methyl benzoate serving 3 - hydroxyl -2 - is used as a raw material, dimethyl sulfate is used as a methylation reagent, and methyl benzoate is produced 3 - methoxy -2 - methyl benzoate in the presence of a base. (4) Hydrolysis Reaction: methyl 3 - methoxy -2 - methyl benzoate and base. Water is mixed, heated and hydrolyzed, the reaction is complete, the product precipitated by acid conditioning PH through 1-3, filtered, and dried to obtain 3 - methoxy -2 -methylbenzoic acid.
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Paragraph 0024; 0030; 0046
(2021/10/20)
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- Low-temperature nematic phase in azo functionalised reactive hockey stick mesogens possessing lateral methyl group
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We report, the design, synthesis and mesomorphic behaviour of new hockey stick mesogens containing photochromic azo group and a reactive double bond. The structure of the compounds resemble the hockey stick due to unequal distribution of the phenyl rings
- Paul, Manoj Kumar,Saha, Sandip Kumar,Kalita, Gayatri,Bhattacharya, Barnali,Sarkar, Utpal
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- ROMATIC COMPOUNDS AND PHARMACEUTICAL USES THEREOF
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The present disclosure relates to compounds of the general formula (I): wherein R1, R2, R3, R4, R5, R6, and R7 may be chosen from different substituents; n is 0, 1, or 2; and X is a hydroxymethyl or a carboxylic acid or a derivative thereof, such as a carboxylate, such as a carboxylic ester, a glyceride, an anhydride, a phospholipid, a carboxamide, a phospholipid, or a prodrug thereof; or a pharmaceutically acceptable salt, solvate, solvate of such salt or a prodrug thereof. The present disclosure also relates to pharmaceutical compositions and lipid compositions comprising at least one compound according to the present disclosure, and to such compounds for use as medicaments or for use in therapy, in particular for the treatment of diseases related to metabolic diseases and liver diseases, such as non-alcoholic fatty liver disease and cholestasis diseases.
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Page/Page column 97
(2020/05/19)
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- Novel achiral four-ring bent-shaped nematic liquid crystals with trifluoromethyl and methyl substituents in the central molecular core: An unusually large Kerr constant in blue phase III of nematic-chiral dopant mixture
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Here, we report the first example of achiral bent-shaped liquid crystals comprising trifluoromethyl and methyl moieties on adjacent phenyl rings in the core, exhibiting nematic mesomorphism close to room temperature on cooling. The XRD confirms the existe
- Khan,Turlapati,Rao,Pratibha,Drzewinski,Dabrowski,Ghosh
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p. 6729 - 6737
(2017/07/22)
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- Design, synthesis and mesomorphic behaviour of a four-ring achiral bent-core liquid crystal in the nematic phase
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Bent-core nematics have attracted growing interest because of the unconventional properties and extraordinary effects exhibited by these liquid crystalline phases. In this report we design, synthesize and characterize four different four-ring achiral bent
- Nafees, Amina,Sinha, Aloka,Rao, Nandiraju V. S.,Kalita, Gayatri,Mohiuddin, Golam,Paul, Manoj Kumar
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p. 43069 - 43079
(2016/05/24)
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- SMALL MOLECULE INHIBITORS OF TLR2 SIGNALING
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The present invention is drawn to therapeutics and methods of inhibiting signaling by TLR2. The invention provides a method of treating an inflammatory disease or condition in a subject comprising administering to the subject a therapeutically effective amount of a compound of the invention or salt, solvate, hydrate, prodrug, metabolite, or combination thereof.
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Page/Page column 31
(2016/12/12)
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- Synthesis and mesomorphic behaviour of achiral four-ring unsymmetrical bent-core liquid crystals: Nematic phases
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Achiral four ring unsymmetrical bent-core liquid crystals derived from 3-amino-2-methylbenzoic acid have been designed and synthesized with an imine, ester and photochromic azo linking moieties. These hockey-stick shape resembling bent molecules possess a
- Paul, Manoj Kumar,Kalita, Gayatri,Laskar, Atiqur Rahman,Debnath, Somen,Gude, Venkatesh,Sarkar, Dipika Debnath,Mohiuddin, Golam,Varshney, Sanjay Kumar,Nandiraju Rao
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- Viscoelasticity, dielectric anisotropy, and birefringence in the nematic phase of three four-ring bent-core liquid crystals with an L-shaped molecular frame
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Molecular shape is an important factor in determining the material properties of thermotropic liquid crystals (LCs). We synthesized and investigated several LC compounds formed by asymmetrically bent molecules with a rigid four-ring core in the shape of t
- Avci, Nejmettin,Borshch, Volodymyr,Sarkar, Dipika Debnath,Deb, Rahul,Venkatesh, Gude,Turiv, Taras,Shiyanovskii, Sergij V.,Rao, Nandiraju V.S.,Lavrentovich, Oleg D.
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p. 1066 - 1075
(2013/03/28)
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- Nematic phases in achiral unsymmetrical four-ring bent-core azo compounds possessing strongly polar cyano and nitro moieties as end substituents: Synthesis and characterization
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Achiral unsymmetrical four-ring bent-core liquid crystals with strongly polar cyano and nitro moieties as substituents at one end and alkyloxy group (butyl to dodecyl) at the other end have been synthesized by a simple and straight forward synthetic method. The four phenyl rings are connected through azo, ester and imine linkages respectively and bent unit is derived from 3-aminobenzoicacid with 2-methyl substituent in the transverse direction of the molecule. The molecular structure characterization is consistent with elemental and spectroscopic analysis data. The materials thermal behaviour and phase characterization have been investigated by differential scanning calorimetry and polarizing optical microscopy. All the compounds exhibit enantiotropic nematic phase over a wide temperature range. The light induced cis-trans isomerization is also discussed.
- Debnath, Somen,Mohiuddin, Golam,Turlapati, Srikanth,Begum, Nazma,Sarkar, Dipika Debnath,Nandiraju Rao
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p. 447 - 455
(2013/10/08)
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- Novel structures derived from 2-[[(2-pyridyl)methyl]thio]-1H-benzimidazole as anti-Helicobacter pylori agents, Part 1
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2-[[(2-Pyridyl)methyl]thio]-1H-benzimidazoles (2, sulfides) exhibit antibacterial properties that are selective for Helicobacter spp., but they also have an inherent susceptibility to metabolic oxidation to furnish 2-[[(2-pyridyl)methyl]sulfinyl]-1H-benzi
- Kühler, Thomas C.,Swanson, Marianne,Christenson, Beritte,Klintenberg, Ann-Charlotte,Lamm, Bo,F?gerhag, Jonas,Gatti, Roberto,?lweg?rd-Halvarsson, Maria,Shcherbuchin, Vladimir,Elebring, Thomas,Sj?str?m, Jan-Erik
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p. 4282 - 4299
(2007/10/03)
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- Synthesis of isothiochroman 2,2-dioxide and 1,2-benzooxathiin 2,2- dioxide gyrase B inhibitors
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The design, synthesis and in vitro biological evaluation of isothiochroman 2,2-dioxide and 1,2-benzooxathiin 2,2-dioxide analogues of coumarin inhibitors of gyrase B are described. Compared to coumarin derivatives, compounds of the 1,2-benzooxathiin 2,2-dioxide series display improved inhibitory potency in negative supercoiling of relaxed DNA gyrase. (C) 2000 Elsevier Science Ltd.
- Peixoto, Christophe,Laurin, Patrick,Klich, Michel,Dupuis-Hamelin, Claudine,Mauvais, Pascale,Lassaigne, Patrice,Bonnefoy, Alain,Musicki, Branislav
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p. 1741 - 1745
(2007/10/03)
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- A formal synthesis of crinipellin B based on the arene-alkene meta- photocycloaddition reaction
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Starting from triethyl phosphonopropionate and 3-nitro-2-methylbenzoic acid, a formal synthesis of crinipellin B was achieved. The strategy draws on the use of a novel version of the arene-alkene meta-photocycloaddition reaction that proceeds with the generation of 4 rings and 4 quaternary stereocenters in one synthetic operation.
- Wender, Paul A.,Dore, Timothy M.
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p. 8589 - 8592
(2007/10/03)
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- Insecticidal N'-substituted-N,N'-diacylhydrazines
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Insecticidal compounds having the formula N-(2-Ra -3-Rb -4-Rh -benzoyl)-N'-(2-Rc -3-Rd -4-Re -5-Rf -benzoyl)-N'-Rg -hydrazine wherein Ra is a halo or lower alkyl; R b is lower alkoxy, optionally substituted with halo (preferably fluoro); Rc is selected from hydrogen, halo, lower alkyl, lower alkoxy, lower alkoxy lower alkyl, and nitro; Rd, Re and Rf are each independently selected from hydrogen, bromo, chloro, fluoro, lower alkyl, lower alkoxy, and lower alkoxy lower alkyl; Rg is a (C4 -C6)alkyl; Rh is hydrogen, lower alkoxy, lower alkyl, or when taken together with Rb is methylenedioxy (--OCH2 O--), 1,2-ethylenedioxy (--OCH2 CH2 O--), 1,2-ethyleneoxy (--CH2 CH2 O--) or 1,3-propyleneoxy (--CH2 CH2 CH2 O--) wherein an oxo atom is located at the Rb position; and the substituents Rc and Rd, or Rd and Re, or Re and Rf when taken together can be methylenedioxy or 1,2-ethylenedioxy as well as compositions comprising an agronomically acceptable carrier and an insecticidally effective amount of such compounds; and methods of using such compounds and compositions. Also, methods for the production of the compounds and their intermediates, which methods comprise either admixing a 3-amino-2-(substituted)-benzoic acid, sodium nitrite and methanol under acidic conditions or admixing a 3,4-fused heterocyclic benzoic acid and an alkyl lithium reagent followed by subsequent reaction with an electrophilic reagent.
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- N-substituted mercaptopropanamide derivatives
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Novel N-substituted mercaptopropanamide derivatives of the formula: STR1 wherein R1 is mercapto or a group convertible into mercapto when cleaved within the biobody, W is hydrogen atom, an alkyl or an aralkyl, R2 is an aryl which may optionally have substituent(s), a heterocyclic group which may optionally have substituent(s), or an alkyl which may optionally have substituent(s), X is a cycloalkylene, a cycloalkylidene, or a phenylene which may optionally have substituent(s) or may optionally be fused with other ring, and R3 is carboxyl or a group convertible into carboxyl when cleaved within the biobody, or a pharmaceutically acceptable salt thereof, and a solid solution of said N-substituted mercaptopropanamide derivative with an amino acid, which have excellent enkephalinase inhibitory activity and are useful for the treatment of mild to moderate pain, and a pharmaceutical composition containing said compounds as an active ingredient, and processes for preparing these compounds.
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- N-substituted mercaptopropanamide derivatives
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Novel N-substituted mercaptopropanamide derivatives of the formula: STR1 wherein R1 is mercapto or a group convertible into mercapto when cleaved within the biobody, W is hydrogen atom, an alkyl or an aralkyl, R2 is an aryl which may optionally have substituent(s), a heterocyclic group which may optionally have substituent(s), or an alkyl which may optionally have substituent(s), X is a cycloalkylene, a cycloalkylidene, or a phenylene which may optionally have substituent(s) or may optionally be fused with other ring, and R3 is carboxyl or a group convertible into carboxyl when cleaved within the biobody, or a pharmaceutically acceptable salt thereof, and a solid solution of said N-substituted mercaptopropanamide derivative with an amino acid, which have excellent enkephalinase inhibitory activity and are useful for the treatment of mild to moderate pain, and a pharmaceutical composition containing said compounds as an active ingredient, and processes for preparing these compounds.
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