- Nitrilase-catalyzed enantioselective synthesis of pyrrolidine- And piperidinecarboxylic acids
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The enantioselective synthesis of the nonproteinogenic amino acids β-proline and nipecotic acids from their readily available nitriles is achieved in high enantiomeric excess by commercially available nitrilases. The presented procedure comprises not more than 4 steps, thus considerably reducing the multiple steps generally required. Amide formation is also observed for specific heterocyclic nitriles.
- Winkler, Margit,Meischler, Dorith,Klempier, Norbert
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p. 1475 - 1480
(2008/09/16)
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- Pyridopyrimidines as nonclassical antifolates
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2-Amino-4-hydroxy-4,5,6,7-tetrahydropyrido[2,3-d]pyrimidine derivatives of aromatic amides, such as a benzamide or thienylcarboxamide in which the amino portion of the amide is other than L-glutamic acid are inhibitors of enzymes which utilize folic acid,
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- Non-classical antifolates
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Compounds of the formula: in which:, Q is -OH or -NH2;, A is -CH2-, -CH2CH2-, -O-, or -S-;, -Ar- is a divalent aromatic ring;, W is -CO- or -SO2; and, Z is: (A) an α-amino acid group of the formula (B
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