Synthesis of silicon analogues of acyclonucleotides incorporable in oligonucleotide solid-phase synthesis
The synthesis of the four silicon analogues of acyclonucleosides was described. In every case, the silicon atom was introduced onto an allyl group on the natural nucleobase following a hydrosilylation reaction. Diols obtained were protected as 4,4'-dimethoxytrityl ethers and subsequently activated as 2-cyanoethyl N,N-diisopropylchlorophosphoramidite in order to be suitable for oligonucleotide solid phase synthesis.
Get Best Price for191086-84-7Acetic acid (acetoxymethyl-methyl-{3-[4-(3-nitro-[1,2,4]triazol-1-yl)-2-oxo-2H-pyrimidin-1-yl]-propyl}-silanyl)-methyl ester