Identification of novel imidazole flavonoids as potent and selective inhibitors of protein tyrosine phosphatase
A series of imidazole flavonoids as new type of protein tyrosine phosphatase inhibitors were synthesized and characterized. Most of them gave potent protein phosphatase 1B (PTP1B) inhibitory activities. Especially, compound 11a could effectively inhibit P
Zhang, Ling,Ge, Yu,Wang, Qing Ming,Zhou, Cheng-He
(2019/04/17)
Bu3SnH mediated oxidative radical cyclisation onto imidazoles and pyrroles
A new protocol using radical cyclisation has been developed for the synthesis of [1,2-c]-fused imidazoles and [1,2-a]-fused pyrroles. The intermediate nucleophilic N-alkyl radicals, generated using Bu3SnH from N- (ω-bromoalkyl) or N-[ω-(phenylselanyl)alkyl] imidazoles and pyrroles, undergo regio-selective radical cyclisalion onto the azole rings followed by oxidative re-aromatisation.
Aldabbagh, Fawaz,Russell Bowman,Mann, Emma,Slawin, Alexandra M.Z.
p. 8111 - 8128
(2007/10/03)
Oxidative radical cyclisations onto imidazoles and pyrroles using Bu3SnH
Oxidative radical cyclisation using Bu3SnH has been used for the synthesis of [1,2-c]-fused imidazoles and [1,2-a]-fused pyrroles from imidazolecarbaldehydes and acylpyrroles respectively. The intermediate nucleophilic N-alkyl radicals cyclise onto imidazole and pyrrole rings followed by oxidative re-aromatisation.
Aldabbagh, Fawaz,Bowman, W. Russell,Mann, Emma
p. 7937 - 7940
(2007/10/03)
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