- Cobalt-Catalyzed Asymmetric Hydrogenation of Vinylsilanes with a Phosphine-Pyridine-Oxazoline Ligand: Synthesis of Optically Active Organosilanes and Silacycles
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The asymmetric hydrogenation of vinylsilanes catalyzed by a new C1-symmetric phosphine-pyridine-oxazoline cobalt complex is described. The method provides an efficient approach to chiral tertiary silanes with enantioselectivities up to 99% ee.
- Zuo, Ziqing,Xu, Songgen,Zhang, Lei,Gan, Lan,Fang, Huaquan,Liu, Guixia,Huang, Zheng
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- Phosphine pyridine oxazoline compound, metal complex, and preparation method and application thereof
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The invention discloses a phosphine pyridine oxazoline compound, a metal complex, and a preparation method and application thereof. According to the invention, the preparation methods of the phosphinepyridine oxazoline compound and the metal complex are s
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Paragraph 0141-0146
(2020/10/04)
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- Enantioselective Synthesis of N-Benzylic Heterocycles: A Nickel and Photoredox Dual Catalysis Approach
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Reported herein is a dual nickel- and photoredox-catalyzed modular approach for the preparation of enantioenriched N-benzylic heterocycles. α-Heterocyclic carboxylic acids, easily obtainable from common commercial material, are reported as suitable substrates for a decarboxylative strategy in conjunction with a chiral pyridine-oxazoline (PyOx) ligand, providing quick access to enantioenriched drug-like products. The presence of a directing group on the heterocyclic moiety is shown to be beneficial, affording improved stereoselectivity in a number of cases.
- Pezzetta, Cristofer,Bonifazi, Davide,Davidson, Robert W. M.
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p. 8957 - 8961
(2019/11/11)
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- Chemoselective oxidation of polyols with chiral palladium catalysts
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Chiral palladium-based catalysts derived from pyridinyl oxazoline (pyOx) ligands catalyze the oxidation of alcohols, including 1,2-diols, triols, and tetraols, with high regio- and chemoselectivity. Screening of various chiral oxazoline-derived ligands for the oxidation of a model diol, 1,2-propanediol (1,2-PD), revealed that the nature of the ligand had a significant influence on the activity and chemoselectivity for oxidation of vicinal diols. The PyOx ligands containing an α-methyl substituent were the most active for the oxidation of 1,2-PD using benzoquinone as the terminal oxidant. Oxidation of vicinal diols and polyols occurs selectively at the secondary alcohol to afford α-hydroxy ketones in isolated yields of 62-87%. Chemoselective oxidation of meso-erythritol with the chiral [(S)-(α-Me(tert-Bu)PyOx)Pd(OAc)] 2[OTf]2 afforded (S)-erthyrulose in 62% yield and 24% ee.
- De Crisci, Antonio G.,Chung, Kevin,Oliver, Allen G.,Solis-Ibarra, Diego,Waymouth, Robert M.
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p. 2257 - 2266
(2013/05/21)
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- Chiral oxazolinylpyridines as ligands for enantioselective palladium catalysed allylic substitution
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Chiral oxazolinylpyridines were prepared and assessed in the enantioselective palladium catalysed allylic substitution of 1,3-diphenylprop-2-enyl acetate with dimethyl malonate. Enantioselectivity up to 91% was obtained.
- Chelucci, Giorgio,Medici, Serenella,Saba, Antonio
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p. 3183 - 3184
(2007/10/03)
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