- Synthesis, characterization, and biological properties of oxidovanadium(IV) complexes of acetylsalicylhydroxamic acid (N-acetyloxy-2-hydroxybenzamide) as potential antimicrobials
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New oxidovanadium(IV) complexes of composition [VO(AcSHA)2] 1 and [VO(acac)(AcSHA)] 2 are synthesized by reactions of VOSO4.5H2O and [VO(acac)2] with acetylsalicylhydroxamic acid AcSH2A (C6H4(OH)(CONHOCOCH3)) in a 1:2 molar ratio in absolute ethanol. The compounds are characterized by the Fourier-transform infrared spectroscopy, ultraviolet–visible spectroscopy, electron spin resonance, and mass spectrometry along with elemental analyses, molar conductivity, and magnetic moment measurements. The infrared spectra of the complexes suggest bonding through carbonyl and phenolic oxygen atoms (O,O coordination). The magnetic moment, electron spin resonance, and mass spectra of the complexes indicate that both exist as monomers, and a distorted square pyramidal geometry around vanadium is proposed. The thermal behavior of the complexes is studied by thermogravimetry and differential thermal analysis techniques under an N2 atmosphere, yielding VO2 as the decomposition product. The in vitro antimicrobial assays against pathogenic Gram-positive bacteria, Gram-negative bacteria, and fungi (minimum inhibitory concentration method) show the appreciable antimicrobial potential relative to the respective standard drugs, tetracycline hydrochloride, and fluconazole.
- Priya, Bhanu,Kumar, Abhishek,Sharma, Neeraj
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- The α-effect in micelles: Nucleophilic substitution reaction of p-nitrophenyl acetate with N-phenylbenzohydroxamate ion
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Pseudo-first-order rate constants have been determined for the nucleophilic substitution reactions of p-nitrophenyl acetate with p-chlorophenoxide (4-ClC6H4O-) and N-phenylbenzohydroxamate (C6H5CON(C
- Ghosh, Kallol K.,Vaidya, Jyoti,Satnami, Manmohan Lal
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- α-effect of hydroxamate ions in micellar mediated reactions of p-nitrophenyl acetate
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The rate-surfactant concentration profiles for the reaction of p-nitrophenyl acetate (PNPA) with three hydroxamate ions (R C6H 4CO NHO-; R = H, 2-OH, 4-OCH3) in aqueous solutions of cetyltrimethylammonium bromide (CTAB) have been studied at 27°C (pH 7.7). In transferring the reaction from water to micelles of CTAB, an increase in reaction rates have been observed.
- Ghosh, Kallol K.,Simanenko, Yurii,Satnami,Sar, Santosh K.
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p. 1990 - 1994
(2007/10/03)
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