Synthesis of a spiro[cyclohex-1,1′-isobenzofuranyl] dopamine receptor antagonist
Two syntheses of the novel CNS agent, 2-fluoro-4-(trans)-(4-(3'H-spiro[cyclohex-l,1'-isobenzofuran]-4-yl)-piperazin-1- yl)benzonitrile, 1, are presented. The first relied on a reductive alkylation with low regioselectivity (1:1) but was sufficient for the
Urban, Frank J.,Anderson, Bruce G.,Stewart, Morgan A.,Young, Gregory R.
This invention relates to novel, pharmaceutically active compounds of formula (I) wherein a, b and R1through R6are as defined in the specification These compounds exhibit central dopaminergic activity and are useful in the treatment
-
Page column 17-18
(2010/02/06)
More Articles about upstream products of 204192-38-1