204192-38-1

Basic information

• Product Name: 2-fluoro-4-(trans)-(4-(3'H-spiro[cyclohex-1,1'-isobenzofuran]-4-yl)piperazin-1-yl)benzonitrile
• Synonyms: 2-fluoro-4-(trans)-(4-(3'H-spiro[cyclohex-1,1'-isobenzofuran]-4-yl)piperazin-1-yl)benzonitrile
• CAS NO: 204192-38-1
• Molecular Weight: 391.488
• Mol File: 204192-38-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-fluoro-4-(trans)-(4-(3'H-spiro[cyclohex-1,1'-isobenzofuran]-4-yl)piperazin-1-yl)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-fluoro-4-(trans)-(4-(3'H-spiro[cyclohex-1,1'-isobenzofuran]-4-yl)piperazin-1-yl)benzonitrile(204192-38-1)
• EPA Substance Registry System: 2-fluoro-4-(trans)-(4-(3'H-spiro[cyclohex-1,1'-isobenzofuran]-4-yl)piperazin-1-yl)benzonitrile(204192-38-1)

Safety Data

• Hazardous Substances Data: 204192-38-1(Hazardous Substances Data)

Upstream product

• 3939-09-1 2,4-difluorobenzonitrile 
• 204192-41-6 3'H-spiro[cyclohexane-1,1'-isobenzofuran]-4-one 
• 69225-59-8 3,3-dimethyl-1,5-dioxaspiro[5.5]undecan-9-one 
• 18982-54-2 o-bromobenzyl alcohol 
• 253800-27-0 1-(3'H-spiro[cyclohex-1,1'-isobenzofuran]-(trans)-4-yl)piperazine 
• 204192-45-0 1-(4-cyano-3-fluoro-phenyl)-piperazine 

Relevant articles and documents

Synthesis of a spiro[cyclohex-1,1′-isobenzofuranyl] dopamine receptor antagonist

Two syntheses of the novel CNS agent, 2-fluoro-4-(trans)-(4-(3'H-spiro[cyclohex-l,1'-isobenzofuran]-4-yl)-piperazin-1- yl)benzonitrile, 1, are presented. The first relied on a reductive alkylation with low regioselectivity (1:1) but was sufficient for the